Death | A bad outcome if untimely | Investigator reported |
Disease | A set of symptoms, physical signs, and laboratory abnormalities | Investigator reported |
Discomfort | Symptoms such as pain, nausea, dyspnoea, itching, and tinnitus | Participant-reported disease-related symptoms |
Disability | Impaired ability to go about usual activities at home, work, or recreation | Participant-reported disease-related impaired function |
Dissatisfaction | Emotional reaction to disease and its care, such as sadness or anger | Participant-reported disease-related bother about impaired function and generic health-related quality of life |