TableĀ 3

Outcomes of disease

OutcomeDescriptionType of outcome
DeathA bad outcome if untimelyInvestigator reported
DiseaseA set of symptoms, physical signs, and laboratory abnormalitiesInvestigator reported
DiscomfortSymptoms such as pain, nausea, dyspnoea, itching, and tinnitusParticipant-reported disease-related symptoms
DisabilityImpaired ability to go about usual activities at home, work, or recreationParticipant-reported disease-related impaired function
DissatisfactionEmotional reaction to disease and its care, such as sadness or angerParticipant-reported disease-related bother about impaired function and generic health-related quality of life