The risk of all-cause mortality, MAC-LD progression mortality and radiographic deterioration in multivariate Cox regression models
| Multivariate Cox regression Final model | |||
|---|---|---|---|
| Variable | Adjusted HR | 95% CI | p Value |
| All-cause mortality (n=782) | |||
| Male (vs female) | 1.958 | 1.357 to 2.823 | <0.001 |
| Age ≥70 years (vs <70 years) | 4.232 | 2.746 to 6.523 | <0.001 |
| Body mass index <18.5 kg/m2 (vs ≥18.5 kg/m2) | 1.725 | 1.093 to 2.723 | 0.019 |
| Some bloody sputum (vs none) | 0.542 | 0.542 to 0.927 | 0.025 |
| ESR ≥40 mm/h (vs <40 mm/h) | 1.849 | 1.140 to 2.999 | 0.013 |
| Alb <3.5 g/dL (vs ≥3.5 g/dL) | 3.159 | 1.708 to 5.844 | <0.001 |
| MAC-LD progression mortality (n=782) | |||
| Age ≥70 years (vs <70 years) | 3.369 | 1.257 to 9.027 | 0.016 |
| Some cavity (vs none) | 11.911 | 4.512 to 31.4444 | <0.001 |
| 2–4 drugs in first-line treatment (vs 0 or 1) | 4.135 | 1.671 to 10.235 | 0.002 |
| Radiographic progression (n=536) | |||
| Underlying IPF (vs none) | 2.191 | 1.325 to 3.624 | 0.002 |
| Haemoglobin <11.3 g/dL (vs ≥11.3 g/dL) | 1.852 | 1.265 to 2.713 | 0.002 |
| CRP ≥1.0 mg/dL (vs <1.0 mg/dL) | 1.520 | 1.081 to 2.136 | 0.016 |
| Some cavity (vs none) | 1.651 | 1.181 to 2.307 | 0.003 |
Alb, albumin; CRP, C reactive protein; ESR, erythrocyte sedimentation rate; IPF, idiopathic pulmonary fibrosis; MAC-LD, Mycobacterium avium complex lung disease.