Table 5

Genotypic and allelic frequency distribution of −384A/C and 584C/T polymorphic of the LIPG gene in male patients and male controls with CAD

CAD
n=204
Control
n=233
p Value*OR (95% CI)
−384A/C
 Genotype frequencyAA125 (61.3%)164 (70.4%)Reference
AC71 (34.8%)61 (26.2%)
CC8 (3.9%)8 (3.4%)0.128
AC+CC79 (38.7%)69 (29.6%)0.0451.502 (1.009 to 2.237)
0.180†1.425(0.849 to 2.390)†
 Allele frequencyA321 (78.7%)389 (83.5%)Reference
C87 (21.3%)77 (16.5%)0.0701.369 (0.974 to 1.924)
584C/T
 Genotype frequencyCC114 (55.9%)127 (54.5%)Reference
CT79 (38.7%)98 (42.1%)
TT11 (5.4%)8 (3.4%)0.523
CT+TT90 (44.1%)106 (45.5%)0.7730.946 (0.648 to 1.380)
 Allele frequencyC307 (75.2%)352 (75.5%)Reference
T101 (24.8%)114 (24.5%)0.9211.016 (0.746 to 1.383)
  • *Compared with controls.

  • †Adjusted by age, gender, TC, TG, HDL-C and LDL-C.

  • CAD, coronary artery disease; HDL-C, high-density lipoprotein cholesterol; LIPG, endothelial lipase gene; LDC-C; low-density lipoprotein cholesterol; TC, total cholesterol; TG, triglyceride.