Table 4

Genotypic and allelic frequency distribution of −384A/C and 584C/T polymorphic of the LIPG gene in patients and controls with CAD

CAD
n=287
Control
n=367
p Value*OR (95% CI)
LIPG −384A/C (rs3813082)
 Genotype frequencyAA184 (64.1%)267 (72.8%)Reference
AC90 (31.4%)90 (24.5%)
CC13 (4.5%)10 (2.7%)0.051
AC+CC103 (35.9%)100 (27.2%)0.0181.495 (1.071 to 2.085)
0.071†1.524 (0.964 to 2.410)†
 
 Allele frequencyA458 (79.8%)624 (85.0%)Reference
C116 (20.2%)110 (15.0%)0.0131.437 (1.078 to 1.915)
LIPG 584C/T (rs2000813)
 Genotype frequencyCC160 (55.7%)216 (58.9%)Reference
CT116 (40.4%)139 (37.9%)
TT11 (3.8%)12 (3.3%)0.711
CT+TT127 (44.3%)151 (41.1%)0.4271.135 (0.831 to 1.552)
 Allele frequencyC436 (76.0%)571 (77.8%)Reference
T138 (24.0%)163 (22.2%)0.4671.109 (0.856 to 1.436)
  • *Compared with controls.

  • †Adjusted by age, gender, TC, TG, HDL-C and LDL-C.

  • HDL-C, high-density lipoprotein cholesterol; LDC-C; low-density lipoprotein cholesterol; TC, total cholesterol; TG, triglyceride.