Table 3

Stratified analysis of associations between TIMP3 rs715572G/A genotypes and knee OA risk using the K–L grading scale

GenotypeModelK–L grading scale*
K–LOR (95% CI)Adjusted OR (95% CI)†
GGAA/GG20.78 (0.49 to 1.24)0.86 (0.53 to 1.41)
GAAA/GG30.56 (0.31 to 1.03)0.60 (0.32 to 1.12)
AAAA/GG40.56 (0.36 to 0.87)0.57 (0.35 to 0.92)
GA/GG20.72 (0.48 to 1.09)0.68 (0.44 to 1.05)
GA/GG30.68 (0.41 to 1.13)0.60 (0.36 to 1.02)
GA/GG40.53 (0.36 to 0.77)‡0.53 (0.35 to 0.80)‡
  • *Grade 0, 1 as a reference category.

  • †Adjusted for age, gender and BMI.

  • ‡p Values were based on Bonferroni's method.

  • BMI, body mass index; K–L, Kellgren–Lawrence; OA, osteoarthritis; TIMP3, tissue inhibitor of metalloproteinases 3.