Analyses of the association of six SNPs with knee OA
| SNP | Case | Control | Crude OR (95% CI) | Adjusted OR (95% CI)* | p Value |
|---|---|---|---|---|---|
| TGF-β1 rs1800469C/T | |||||
| T/T | 166 | 167 | 1 | 1 | |
| T/C | 238 | 212 | 1.03 (0.96 to 1.11) | 1.19 (0.88 to 1.61) | 0.254 |
| C/C | 114 | 89 | 1.07 (0.98 to 1.16) | 1.27 (0.87 to 1.84) | 0.214 |
| C allele | 0.45 | 0.42 | 1.16 (0.96 to 1.37) | 1.14 (0.95 to 1.38) | 0.167 |
| TGF-βRI rs1590A/G | |||||
| A/A | 199 | 167 | 1 | 1 | |
| C/A | 227 | 208 | 0.98 (0.91 to 1.05) | 0.95 (0.70 to 1.28) | 0.717 |
| C/C | 92 | 93 | 0.96 (0.87 to 1.04) | 0.91 (0.63 to 1.33) | 0.636 |
| C allele | 0.40 | 0.42 | 0.91 (0.76 to 1.08) | 0.95 (0.78 to 1.51) | 0.602 |
| Smad3 rs12901499A/G | |||||
| A/A | 142 | 116 | 1 | 1 | |
| G/A | 274 | 228 | 0.97 (0.90 to 1.05) | 0.86 (0.62 to 1.19) | 0.360 |
| G/G | 129 | 124 | 0.96 (0.88 to 1.05) | 0.87 (0.60 to 1.26) | 0.447 |
| G allele | 0.49 | 0.51 | 0.92 (0.77 to 1.8) | 0.93 (0.77 to 1.12) | 0.434 |
| Smad3 rs6494629T/C | |||||
| T/T | 241 | 184 | 1 | 1 | |
| C/T | 215 | 214 | 0.94 (0.88 to 1.00) | 0.79 (0.59 to 1.05) | 0.107 |
| C/C | 62 | 70 | 0.91 (0.82 to 1.00) | 0.79 (0.52 to 1.20) | 0.262 |
| C allele | 0.33 | 0.38 | 0.80 (0.66 to 0.96) | 0.86 (0.70 to 1.04) | 0.119 |
| TIMP3 rs715572G/A | |||||
| G/G | 157 | 100 | 1 | 1 | |
| G/A | 236 | 242 | 0.89 (0.83 to 0.96) | 0.64 (0.46 to 0.88) | 0.007† |
| A/A | 125 | 126 | 0.89 (0.82 to 0.97) | 0.71 (0.49 to 1.03) | 0.071 |
| A allele | 0.47 | 0.53 | 0.79 (0.66 to 0.94) | 0.84 (0.69 to 1.01) | 0.065 |
| TIMP3 rs1962223G/C | |||||
| G/G | 173 | 155 | 1 | 1 | |
| C/G | 259 | 240 | 0.99 (0.93 to 1.06) | 0.96 (0.71 to 1.58) | 0.792 |
| C/C | 86 | 73 | 1.01 (0.92 to 1.11) | 1.05 (0.71 to 1.29) | 0.790 |
| C allele | 0.42 | 0.41 | 1.02 (0.85 to 1.22) | 1.01 (0.84 to 1.23) | 0.840 |
*Adjusted for age, gender and BMI.
†p Values were based on Bonferroni's method.
BMI, body mass index; OA, osteoarthritis; Smad3, Smad family member 3; SNPs, single nucleotide polymorphisms; TGF, transforming growth factor; TIMP3, tissue inhibitor of metalloproteinases 3.