ADR | VPA | CBZ | LTG | Others | Total |
---|---|---|---|---|---|
Psychiatry | |||||
Behavioural problems | 8 | 7 | 3 | TPM (1), PHT (1), LEV (2) | 22 |
Depression | 1 | 1 | – | – | 2 |
Anxiety | – | 1 | – | – | 1 |
Skin and appendage | |||||
Rash | – | 5 | 3 | PBT (1) | 9 |
Steven-Johnson syndrome | PBT (1), PHT (1) | 2 | |||
Hair loss | 4 | – | – | – | 4 |
Metabolic | |||||
Increased appetite | 2 | 1 | – | – | 3 |
Reduced appetite | – | 1 | – | – | 1 |
Weight gain | 1 | 1 | – | – | 2 |
Polydipsia | 1 | – | – | – | 1 |
Nervous system | |||||
Somnolence/sleep disorders | 2 | 6 | 2 | CLB (4), ETX (1), PBT (1), PHT (1), LEV (1) | 18 |
Headache | 2 | – | 2 | – | 4 |
Fatigue | 2 | 2 | – | – | 4 |
Dizziness | – | 1 | 2 | – | 3 |
Blurred vision | – | 3 | – | – | 3 |
Poor concentration | – | – | – | TPM (1), LEV (1) | 2 |
Auditory hallucination | 1 | – | – | – | 1 |
Tremor | 1 | – | – | – | 1 |
Paraesthesia | – | – | – | TPM (1) | 1 |
Dystonia | – | – | – | PHT (2) | 2 |
Increased/new seizure | – | – | – | TPM (1), OXC (1) | 2 |
Gastrointestinal | |||||
Nausea | 2 | 2 | – | ETX (1) | 5 |
Vomiting | 1 | 2 | 1 | 4 | |
Abdominal pain | 1 | – | 1 | TPM (1) | 3 |
Diarrhoea | – | – | 1 | – | 1 |
Others | |||||
Fever | – | 1 | – | – | 1 |
Enuresis | 1 | – | – | TPM (1) | 2 |
Incontinence | – | 1 | – | – | 1 |
Renal stone | – | – | – | TPM (1) | 1 |
Respiratory arrest | – | – | – | Paraldehyde (1) | 1 |
Thrombocytopenia/bruising | 3 | – | – | LEV (1) | 4 |
Elevated ALT | 1 | – | – | – | 1 |
Gum hypertrophy | 1 | PHT (1) | 2 | ||
Total | 34 | 36 | 15 | 29 | 114 |
ALT, alanine transaminase; ADRs, adverse drug reactions; CBZ, carbamazepine; CLB, clobazam; ETX, ethosuximide; LEV, levetiracetam; LTG, lamotrigine; OXC, oxcarbazepine; PBT, phenobarbital; PHT, phenytoin; TPM, topiramate; VPA, valproic acid.