Table 1

Inclusion and exclusion criteria

Inclusion criteria	Exclusion criteria
Age >18 years Symptomatic acute pulmonary embolism with first clinical symptoms within 15 days, and objectively confirmed by CT scan RV dysfunction confirmed by echocardiography or spiral CT of the chest: ▸ Echocardiography (≥1 criterion): RV/LV end-diastolic diameter >1 (apical or subcostal 4-chamber view) ▸ CT: right/left short-axis diameter ratio >0.9 (transverse plane) ▸ BNP >200 pg/mL or NT-pro BNP >600 pg/mL One abnormal PESI criteria: ▸ Heart rate >110/min ▸ Systolic blood pressure <100 mm Hg ▸ Arterial oxyhaemoglobin level <90%	Cardiogenic shock requiring thrombolysis Significant LV insufficiency (LVEF <45%) Systolic blood pressure <90 mm Hg at admission Age ≤18 years Pregnancy No health insurance Patients deprived of liberty or under legal protection

Inclusion criteria

Exclusion criteria

Age >18 years
Symptomatic acute pulmonary embolism with first clinical symptoms within 15 days, and objectively confirmed by CT scan
RV dysfunction confirmed by echocardiography or spiral CT of the chest: ▸ Echocardiography (≥1 criterion): RV/LV end-diastolic diameter >1 (apical or subcostal 4-chamber view) ▸ CT: right/left short-axis diameter ratio >0.9 (transverse plane) ▸ BNP >200 pg/mL or NT-pro BNP >600 pg/mL
One abnormal PESI criteria: ▸ Heart rate >110/min ▸ Systolic blood pressure <100 mm Hg ▸ Arterial oxyhaemoglobin level <90%

BNP, brain natriuretic peptide; LV, left ventricular; LVEF, left ventricular ejection fraction; PESI, Pulmonary Embolism Severity Index; RV, right ventricular.