Table 3

Association between breathlessness and confounders for the recessive mode of inheritance in the morphine population

Univariable analysisMultivariable analysis
OR (95% CI)p ValueORp Value
HTR3B_rs71035722.86 (1.31 to 6.21)0.0082.86 (1.46 to 5.62)0.002
ARRB2_rs10452800.846 (0.59 to 1.22)0.360.97 (0.62 to 1.62)0.89
Age (per year)1.00 (0.99 to 1.01)0.901.00 (0.98 to 1.02)0.73
Male gender1.05 (0.84 to 1.31)0.691.06 (0.78 to 1.45)0.70
Body mass index (per 1 kg/m2)1.03 (0.98 to 1.08)0.321.03 (0.97 to 1.09)0.39
Karnofsky status (per 1 point)0.83 (0.75 to 0.92)<0.0010.83 (0.72 to 0.96)0.011
Time on opioids (per month)0.99 (0.97 to 1.00)0.170.99 (0.97 to 1.00)0.15
Morphine daily dose (per 100 mg increments)1.00 (1.00 to 1.00)0.171.00 (1.00 to 1.00)0.469
Pain1.19 (1.03 to 1.39)0.0221.13 (0.84 to 1.52)0.41