Association between breathlessness and confounders for the recessive mode of inheritance in the morphine population
| Univariable analysis | Multivariable analysis | |||
|---|---|---|---|---|
| OR (95% CI) | p Value | OR | p Value | |
| HTR3B_rs7103572 | 2.86 (1.31 to 6.21) | 0.008 | 2.86 (1.46 to 5.62) | 0.002 |
| ARRB2_rs1045280 | 0.846 (0.59 to 1.22) | 0.36 | 0.97 (0.62 to 1.62) | 0.89 |
| Age (per year) | 1.00 (0.99 to 1.01) | 0.90 | 1.00 (0.98 to 1.02) | 0.73 |
| Male gender | 1.05 (0.84 to 1.31) | 0.69 | 1.06 (0.78 to 1.45) | 0.70 |
| Body mass index (per 1 kg/m2) | 1.03 (0.98 to 1.08) | 0.32 | 1.03 (0.97 to 1.09) | 0.39 |
| Karnofsky status (per 1 point) | 0.83 (0.75 to 0.92) | <0.001 | 0.83 (0.72 to 0.96) | 0.011 |
| Time on opioids (per month) | 0.99 (0.97 to 1.00) | 0.17 | 0.99 (0.97 to 1.00) | 0.15 |
| Morphine daily dose (per 100 mg increments) | 1.00 (1.00 to 1.00) | 0.17 | 1.00 (1.00 to 1.00) | 0.469 |
| Pain | 1.19 (1.03 to 1.39) | 0.022 | 1.13 (0.84 to 1.52) | 0.41 |