Table 2

SIR of COPD in adoptees with COPD in biological and adoptive parents (N=80 214)

MalesFemalesAll
Age at diagnosis (years)OSIR95% CIOSIR95% CIOSIR95% CI
Both biological and adoptive parents without COPD693Reference892Reference1585Reference
Both biological and adoptive parents with COPD
 <50141.490.81 to 2.51211.761.092.69351.641.14 to 2.28
 50–59272.251.48 to 3.28271.691.112.47541.931.45 to 2.52
 ≥6090.970.44 to 1.85231.691.072.53321.400.96 to 1.97
 All501.631.21 to 2.15711.711.332.161211.681.39 to 2.00
Only biological parents with COPD
 <50201.851.13 to 2.86292.291.533.29492.081.54 to 2.76
 50–59282.061.36 to 2.97412.331.673.16692.211.72 to 2.80
 ≥60131.080.57 to 1.84312.081.412.96441.631.19 to 2.19
 All611.671.28 to 2.151012.241.822.721621.981.69 to 2.31
Only adoptive parents with COPD
 <5080.870.37 to 1.7380.750.321.49160.810.46 to 1.32
 50–59151.070.60 to 1.77211.150.711.77361.120.78 to 1.55
 ≥60241.130.72 to 1.68341.370.951.92581.260.96 to 1.63
 All471.060.78 to 1.41631.180.901.511101.120.92 to 1.35
  • Bold: 95% CI does not include 1.00.

  • SIRs are adjusted for sex (not sex-specific SIRs), age, time period, geographic region of residence and educational level. SIRs for males are calculated only for males with and without a family history, and SIRs for females are calculated only for females with and without a family history.

  • COPD, chronic obstructive pulmonary disease; O, observed number of cases; SIR, standardised incidence ratio.