Table 3

Summary of subgroup analysis of the included studies by different study characteristics

VariablesNumber of studiesSensitivity (95% CI)Specificity (95% CI)Likelihood ratio+Likelihood ratio–AUROC (95% CI)Diagnostic OR (95% CI)I2 (95% CI)Publication bias (Egger's test p)
Overall70.89 (0.79 to 0.95)0.77 (0.62 to 0.88)4.0 (2.30 to 6.90)0.14 (0.07 to 0.27)0.91 (0.88 to 0.93)26.9 (10.33 to 69.96)73.7 (43.8 to 87.7)0.057
NT-pro BNP60.89 (0.78 to 0.95)0.72 (0.58 to 0.82)3.20 (2.10 to 4.80)0.15 (0.07 to 0.31)0.87 (0.83 to 0.89)21.6 (8.33 to 55.97)73.2 (38.5 to 88.3)0.146
  • AUROC, area under the receiver operating characteristic curve; BNP, B-type natriuretic peptide; NT-proBNP, N-terminal prohormone serum BNP.