Low molecular weight antioxidants in bronchial wash (BW) and bronchoalveolar lavage (BAL) in patients with asthma and healthy individuals
| Antioxidant | Healthy controls n=16 | Patients with asthma n=16 | p Value |
|---|---|---|---|
| Bronchial RTLF | |||
| Ascorbate (μM) | 10.5 (0.0–71.0) | 6.39 (0.0–97.9) | 0.92 |
| Dehydroascorbate (μM) | 40.7 (33.0–57.0 | 38.5 (21.2–53.0) | 0.58 |
| Vitamin C (μM) | 52.3 (37.3–138) | 49.1 (23.0–149) | 0.72 |
| GSH (μM) | 323 (277–605) | 348 (205–442) | 0.49 |
| GSSG (μM) | 52.3 (32.0–75.7) | 43.4 (15.6–94.0) | 0.71 |
| GSx (μM) | 508 (350–757) | 465 (287–622) | 0.49 |
| Alveolar RTLF | |||
| Ascorbate (μM) | 103 (81.2–150.1) | 79.4 (55.7–119) | 0.10 |
| Dehydroascorbate (μM) | 16.2 (10.8–20.4) | 16.9 (12.0–23.9) | 0.65 |
| Vitamin C (μM) | 118 (96.5–174) | 93.2 (75.8–139) | 0.14 |
| GSH (μM) | 124 (101–181) | 126 (46.6–219) | 0.50 |
| GSSG (μM) | 21.3 (17.2–37.5) | 19.3 (12.1–26.5) | 0.25 |
| GSx (μM) | 162 (127–195) | 177 (81.4–244) | 0.84 |
Data are presented as median (IQR). Values are corrected for urea dilution.
GSH, reduced glutathione; GSSG, glutathione disulfide (oxidised glutathione); GSx, total glutathione; RTLF, respiratory tract lining fluid.