Comparison of M-OS, M-TTP and M-PFS, between the vaccine and control groups
| Event | Number of trials | Number of pts | Number of pts | Mean difference | 95% CI | p Value | Heterogeneity (I2), % | HR | 95% CI | p Value | Heterogeneity (I2), % |
|---|---|---|---|---|---|---|---|---|---|---|---|
| vaccine | control | ||||||||||
| M-OS | 914–18 20 21 23 24 | 1362 | 985 | 2.77 | 1.79 to 3.75 | <0.00001 | 99 | 0.760 | 0.644 to 0.896 | 0.001 | 24.9 |
| M-TTP | 315 22 23 | 1113 | 693 | 1.00 | 0.39 to 1.61 | 0.001 | 99 | NA | NA | NA | NA |
| M-PFS | 414 19–21 | 998 | 648 | 1.03 | 0.31 to 1.74 | 0.005 | 97 | 0.842 | 0.744 to 0.954 | 0.007 | 0 |
Significant difference: p value <0.05. M-OS, median overall survival; M-PFS, median progression-free survival; M-TTP, median time to progression; NA, not available; pts, patients.