Postrandomisation treatment group comparison of demographic, social and clinical characteristics
| High-DHA diet (n=291) | Standard-DHA diet (n=313) | p Value | |
|---|---|---|---|
| Social variables | |||
| Mean, SD corrected age at primary outcome assessment, years (n=284/293) | 7.2 (0.4) | 7.2 (0.3) | 0.69 |
| Death between 18 months and 7 years’ corrected age (n=313/326*) | 0 (0.0) | 2 (0.6) | 0.50† |
| Family unblinded before the 7-year corrected age assessment | 6 (2.1) | 6 (1.9) | >0.99 |
| English primary language spoken at home (n=285/298) | 278 (97.5) | 296 (99.3) | 0.10 |
| Living in two parent family‡ (n=285/298) | 214 (75.1) | 237 (79.5) | 0.23† |
| Mean (SD) Recent Life Events, total events (n=278/290) | 2.5 (2.5) | 2.2 (2.4) | 0.20 |
| Mean (SD) Recent Life Events, total events still impacting (n=278/290) | 0.5 (1.2) | 0.4 (1.0) | 0.47 |
| Mean (SD) Family Assessment Device general functioning score (n=278/289) | 1.6 (0.4) | 1.5 (0.4) | 0.24 |
| Dietary variables | |||
| Had fish in the last month (n=285/298) | 248 (87.0) | 267 (89.6) | 0.39 |
| Mean (SD) number of fish meals in the last month (n=246/266) | 5.0 (3.8) | 5.1 (3.6) | 0.96 |
| Had DHA-enriched foods in the last month (n=285/298) | 172 (60.4) | 181 (60.7) | 0.93 |
| Mean (SD) number of DHA-enriched foods in the last month (n=164/173) | 21.2 (26.4) | 16.8 (18.2) | 0.16 |
| Had a supplement containing DHA in the last month (n=283/293) | 73 (25.8) | 57 (19.5) | 0.10 |
Values are numbers (percentage) of infants unless stated otherwise.
*Denominator based on randomised infants still alive at the completion of DINO.
†Fisher exact p Value.
‡Families with biological parents living together and new marriage/de facto relationship.
DHA, docosahexaenoic acid; DINO, DHA for the Improvement of Neurodevelopmental Outcome in preterm infants trial.