Table 2

Most common combinations of conditions and medications in patients with fibromyalgia

Condition 1Condition 2N (%)
Chronic joint pain/degenerative arthritisDepression749 (67.4)
Chronic joint pain/degenerative arthritisChronic headaches/migraines628 (56.5)
Chronic joint pain/degenerative arthritisAnxiety569 (51.2)
DepressionAnxiety560 (50.4)
DepressionChronic headaches/migraines553 (49.8)
Chronic joint pain/degenerative arthritisInsomnia524 (47.2)
Chronic joint pain/degenerative arthritisObesity (BMI >30)467 (43.2)
Chronic joint pain/degenerative arthritisHypertension473 (43.0)
Medication 1Medication 2
Sleep aidsSSRI130 (11.7)
Sleep aidsOpioids103 (9.3)
Sleep aidsOther psychiatric medications*101 (9.1)
Sleep aidsSNRI97 (8.7)
Sleep aidsα-2-δ ligands92 (8.3)
OpioidsSSRI88 (7.9)
Sleep aidsTramadol85 (7.7)
Sleep aidsBenzodiazepines80 (7.2)
  • *Other psychiatric medications include lithium, monoamine oxidase inhibitors, antipsychotics, bupropion, lamotrigine and tetracyclic antidepressants.

  • BMI, body mass index; SNRI, serotonin norepinephrine reuptake inhibitor; SSRI, selective serotonin reuptake inhibitor.