*Statin use is modelled as time varying covariate. That is, USE(t)=0 when patient is not taking statin and USE(t)=1 once patient begins taking statin.

†Model 1 adjusted for age, income, marital status, enrolment status in the HT, DM and extension study, baseline history of cerebrovascular disease, hypertension, use of antiplatelet agents and anticoagulants.

‡Model 2 adjusted for variables in model 1 plus BMI, waist-to-hip ratio, physical activity, smoking status, baseline history of diabetes, baseline history of high cholesterol requiring pharmacological treatment and baseline history of cardiac disease.

§Adjusted for same variables as model 1 and include interactions terms, statin use and antiplatelet use, statin use and anticoagulant use.

¶Antiplatelet agents included aspirin, dipyridamole and ticlopidine; anticoagulants included warfarin and heparin. See text for definitions of each study variable.

BMI, body mass index; DM, dietary modification; HT, hormone therapy.