Table 1

Schedule of enrolment, interventions, and assessments

			Study period
	Enrolment	Allocation	Postallocation
Study visit number		1	1	2	3	4	5
Age (months)		1	1	2	4	6	7
Allocation		x
Eligibility screen	x	x
Informed consent	x	x
Interventions
Group 1 PHiD-CV10				x	x	x
Group 2 PCV13				x	x	x
Group 3 PHiD-CV10 PCV13			x	x	x
Group 3 PHiD-CV10 PCV13						x
Assessments
Risk factors
Fixed, eg, sex, birth weight, gestational age, maternal education		x
Not fixed, eg, household occupancy, smoke exposure, breastfeeding		x					x
Ear assessment
Tympanometry			x	x	x	x	x
Otoscopy					x	x	x
Nasopharyngeal swab				x	x	x	x
Blood draw (heel prick or venepuncture)				x*	x*		x
General health (skin, chest, nose, temp, weight, length)			x	x	x	x	x

*Blood draw occurs at either 2 or 4 months of age (decided by a random process).