Table 2

Interim prioritisation of the top 26 uncertainties

UncertaintyPwP ScoreCarer ScoreF&F ScoreHSCP ScoreTotalInterim rankA–Z ID
What treatments are helpful in reducing tremor in people with Parkinson's?938392913591T
What treatments are helpful for reducing balance problems and falls in people with Parkinson's?929380943591E
Is it possible to identify different types of Parkinson's, eg, tremor dominant? And can we tailor treatments best according to these different types?888889883533U
What treatments would ensure the medications were equally effective each day (prevented/managed wearing off, variability, on/off states) in people with Parkinson's?899488813524H
Would the monitoring of dopamine levels in the body (eg, with blood tests) be helpful in determining medication timing and amount (dose)?918986863524L
What is helpful for improving the quality of sleep in people with Parkinson's?9479.59384350.56G
What best treats mild cognitive problems such as memory loss, lack of concentration, indecision and slowed thinking in people with Parkinson's?87917789.5344.57D
What treatments are helpful in reducing urinary problems (urgency, irritable bladder, incontinence) in people with Parkinson's?907794793408I
What drug treatments are best for the different stages of Parkinson's?83878777.5334.59X
What approaches are helpful for reducing stress and anxiety in people with Parkinson's?7577829232610M
What treatments are helpful for reducing dyskinesias (involuntary movements, which are a side effect of some medications) in people with Parkinson's?809073.577.532111J
What best treats dementia in people with Parkinson's?5692759331612Z
What interventions are effective for reducing or managing unexplained fatigue in people with Parkinson's?7865858531313Y
What best helps prevent or reduce freezing (of gait and in general) in people with Parkinson's?7971.57682308.514O
What treatments are helpful for swallowing problems (dysphagia) in people with Parkinson's?6674.58180301.515C
What is the best method of monitoring a person with Parkinson's response to treatments?8152.583.58330016F
What training, techniques or aids are needed for hospital staff, to make sure patients with Parkinson’s get their medications correctly and on time?538664.589.529317W
What treatments are helpful in reducing bowel problems (constipation, incontinence) in people with Parkinson's?7785904029218K
What is the best type and dose of exercise (physiotherapy) for improving muscle strength, flexibility, fitness, balance and function in people with Parkinson's?846864.567.528419Q
Can medications be developed to allow fewer doses per day for people with Parkinson's? (For example combinations of medications in one pill, slow release pills)7384566928220S
What helps improve the dexterity (fine motor skills or coordination of small muscle movements) of people with Parkinson's so they can do up buttons, use computers, phones, remote controls etc?8559.573.554.5272.521A
What treatments are effective in reducing hallucinations (including vivid dreams) in people with Parkinson's?5279.571.56126422P
What is the best treatment for stiffness (rigidity) in people with Parkinson's?8667634626223B
At which stage of Parkinson's is deep brain stimulation (a surgical treatment that involves implanting a ‘brain pacemaker’ that sends signals to specific parts of the brain) most helpful?6959.59142261.524N
What training to improve knowledge and skills do informal carers (family and friends) need in order to best care for people with Parkinson's?42827063.5257.525V
What is the best treatment for pain in people with Parkinson's?825460.557.525426R
  • F&F, family and friends; HSCP, health and social care professionals; PwP, people with Parkinson's.