Median (IQR) daily dose for the three most prescribed first-generation and second-generation antipsychotics by indication
| Diagnosis | Haloperidol | Chlorpromazine | Trifluoperazine | Olanzapine | Quetiapine | Risperidone | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Median | IQR | Median | IQR | Median | IQR | Median | IQR | Median | IQR | Median | IQR | |
| SMI* | ||||||||||||
| Schizophrenia | 7 | (3, 14) | 103 | (55, 208) | 10 | (5, 18) | 12 | (9, 19) | 326 | (171, 546) | 4 | (2, 6) |
| Bipolar disorder | 5 | (2, 11) | 93 | (50, 174) | 5 | (2, 10) | 10 | (6, 15) | 239 | (100, 413) | 2 | (1, 4) |
| Other SMI | 3 | (1, 6) | 88 | (50, 171) | 6 | (2, 12) | 10 | (6, 15) | 174 | (70, 337) | 2 | (1, 4) |
| On SMI register only | 4 | (1, 8) | 91 | (51, 159) | 4 | (2, 8) | 9 | (5, 12) | 119 | (54, 254) | 2 | (1, 4) |
| Non-SMI* | ||||||||||||
| Any non-SMI diagnosis | 2 | (1, 3) | 62 | (38, 109) | 3 | (2, 5) | 6 | (4, 10) | 66 | (38, 132) | 1 | (1, 2) |
| ADHD | 2 | (1, 5) | 82 | (50, 184) | 3 | (2, 5) | 7 | (5, 11) | 100 | (50, 210) | 1 | (1, 2) |
| Anxiety | 1 | (1, 3) | 61 | (36, 108) | 3 | (2, 4) | 6 | (4, 10) | 80 | (46, 177) | 1 | (1, 3) |
| Depression | 2 | (1, 3) | 58 | (37, 102) | 3 | (2, 5) | 6 | (4, 10) | 79 | (43, 167) | 1 | (1, 2) |
| Dementia | 1 | (1, 3) | 75 | (39, 170) | 3 | (2, 7) | 5 | (3, 8) | 52 | (30, 89) | 1 | (1, 2) |
| OCD | 2 | (1, 5) | 75 | (42, 118) | 3 | (2, 5) | 5 | (4, 10) | 95 | (50, 205) | 1 | (1, 2) |
| PD | 2 | (1, 6) | 82 | (48, 150) | 4 | (2, 7) | 8 | (5, 12) | 141 | (58, 292) | 2 | (1, 3) |
| PTSD | 2 | (1, 3) | 64 | (38, 138) | 2 | (2, 5) | 6 | (4, 10) | 100 | (54, 232) | 2 | (1, 3) |
| Sleep disorders | 3 | (1, 8) | 79 | (49, 151) | 4 | (2, 11) | 10 | (6, 15) | 155 | (58, 340) | 2 | (1, 4) |
| None of the above* | 2 | (1, 4) | 70 | (38, 128) | 2 | (1, 5) | 7 | (4, 11) | 56 | (30, 119) | 2 | (1, 3) |
*If a person has an SMI diagnosis, any non-SMI diagnoses will not be included in the numbers below. For those who do not have an SMI diagnosis, all non-SMI diagnoses will be shown (ie, they are not mutually exclusive). ‘None of the above’ means not having an SMI diagnosis or any of the non-SMI diagnoses in the table.
ADHD, attention deficit hyperactivity disorder; OCD, obsessive compulsive disorder; PD, personality disorder; PTSD, post-traumatic stress disorder; SMI, serious mental illness.