Baseline characteristics
| Total (n=1008) | Non-HPR (n=665; 66%) | Individualised (n=343; 34%) | p Value | |
|---|---|---|---|---|
| Age | 64.7±11.8 | 65.1±11.7 | 63.9±11.9 | NS |
| Women | 303 (30%) | 183 (28%) | 120 (35%) | 0.01 |
| Body mass index (kg/m2) | 28.4±4.6 | 28.1±4.5 | 29.1±4.8 | 0.001 |
| Diabetes | 321 (32%) | 196 (30%) | 125 (36%) | 0.03 |
| Insulin treatment | 84 (8%) | 41 (6%) | 43 (13%) | 0.001 |
| Oral medication | 237 (24%) | 155 (23%) | 82 (24%) | NS |
| Smoker | 504 (50%) | 334 (50%) | 170 (50%) | NS |
| Hypertension | 842 (84%) | 557 (84%) | 285 (83%) | NS |
| Hyperlipidaemia | 855 (85%) | 552 (83%) | 303 (88%) | 0.03 |
| Family history | 272 (27%) | 181 (27%) | 91 (27%) | NS |
| History of myocardial infarction | 212 (21%) | 139 (21%) | 73 (21%) | NS |
| History of PCI | 190 (19%) | 130 (20%) | 60 (18%) | NS |
| History of CABG | 60 (6%) | 42 (6%) | 18 (5%) | NS |
| Cerebrovascular disease | 115 (11%) | 71 (11%) | 44 (13%) | NS |
| Peripheral vascular disease | 133 (13%) | 92 (14%) | 41 (12%) | NS |
| Clinical presentation | <0.001 | |||
| STEMI | 93 (9%) | 31 (5%) | 62 (18%) | |
| NSTE-ACS | 447 (44%) | 304 (46%) | 143 (41%) | |
| NSTEMI | 393 (39%) | 261 (39%) | 132 (38%) | |
| Unstable angina | 54 (5%) | 43 (7%) | 11 (3%) | |
| Stable angina | 468 (47%) | 330 (50%) | 138 (41%) | |
| Cardiogenic shock | 26 (3%) | 8 (1%) | 18 (5%) | <0.001 |
| Platelet count ×103/µL | 251±81 | 239±74 | 276±88 | <0.001 |
| Comedication | ||||
| Statin | 929 (92%) | 612 (92%) | 317 (92%) | NS |
| Proton pump inhibitor | 649 (64%) | 397 (60%) | 252 (74%) | <0.001 |
| Calcium channel blocker | 195 (19%) | 116 (17%) | 79 (23%) | 0.03 |
| β blocker | 771 (77%) | 515 (77%) | 256 (75%) | NS |
| ACE-I/ARB | 764 (76%) | 494 (74%) | 270 (79%) | NS |
ARB, angiotensin receptor blocker; CABG, coronary artery bypass graft; HPR, high on-treatment platelet reactivity; NSTE-ACS, non-ST-elevation acute coronary syndrome; NS, not significant; NSTEMI, non-ST-Elevation myocardial infarction; PCI, percutaneous coronary intervention; STEMI, ST-elevation myocardial infarction.