Diagnostic codes for secondary outcomes
| Outcome | Definition | ICD-9 | ICD-10 |
|---|---|---|---|
| (1) CVD—total | Major cardiovascular disease | CVD main events as defined in table 1 | CVD main events as defined in table 1 |
| Transient ischemic attack | 435 | G45 (excluding G454) | |
| Congestive heart failure | 428 | I50 | |
| Other acute coronary syndrome | 411, 413 | I20, I23.82, I24 | |
| Peripheral vascular disease (amputation and bypass) | CCP codes | CCI codes | |
| Leg amputation* | 96.14, 96.15 | 1VQ93, 1VC93, 1VG93 | |
| Foot or toe amputation* | 96.11, 96.12, 96.13 | 1WM93, 1WL93, 1WA93, 1WE93, 1WJ93 | |
| Arterial bypass surgery† | 51.25, 51.29 | 1KG76 | |
| Percutanous transluminal angioplasty† | 50.18 | 1KG50, 1KG57,1KG76, 1KG35HAC1, 1KG35HHC1 | |
| (2) Major coronary artery disease | Acute myocardial infarct | 410 | I21, I22 |
| (3) Coronary artery disease—total | Acute myocardial infarct | 410 | I21, I22 |
| Other acute coronary syndrome | 411, 413 | I20, I23.82, I24 | |
| (4) Stroke—major | Stroke hospitalisation or death | Hospital—430, 434, 436, 362.3 Death—430–434, 436–438 | I60, I61, I63 (excluding I63.6), I64, H341 I60—I69 |
| (5) Stroke—minor | Stroke—major and stroke, hospitalised TIA, stroke or TIA diagnosed in the outpatient setting | Same as stroke—major Stroke in the community setting as ascertained by Tu et al35 | Same as stroke—major Stroke in the community setting as ascertained by Tu et al35 |
| Sensitivity testing (inclusion of less commonly used diagnostic codes) | |||
| Acute stroke | 362.3 | I65 | |
| Stroke/TIA | 437.1, 437.9, 438 | I67.8, I67.9, I69 | |
*Exclude all upper leg or foot amputations if in conjunction with [ICD9: 170, 171, 213, 730, 740–759, 800–900, 901–904, 940–950 ICD10: C40, C41, C46.1, C47, C49, D160, M46.2, M46.2, M86, M87, M89.6, M90.0-M90.5, Q00, Q38-Q40, S02.0, S09.0, S04.0, S15, S25, S25, T26].
†Exclude all records with a diagnosis code of aneurysm [ICD9: 4141, 441, 442, ICD10: I67.1, I71, I72, I60, 177.0, 179.0, Q codes].
CCI, Canadian Classification of Health Interventions; CCP, Canadian Classification of Diagnostic, Therapeutic and Surgical Procedures; CVD, cardiovascular disease; ICD, The International Classification of Diseases, Ninth Revision; TIA, transient ischemic attack.