Analysis plan detailing the outcomes and the covariates that will be considered for adjustment in the statistical models
| Primary outcome | Secondary outcomes | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Birth weight | Booking status | Measures of stage | Measures of size: | Other birth outcomes | Maternal smoking during this pregnancy | |||||||
| Gestation at booking | Booking before 25 weeks | Gestational age at delivery | Term at birth | Weight-for-dates | Head circumference, | Mode of delivery | Stillbirth | 5 min Apgar score | Neonatal death | |||
| Covariates | Crown to heel length | |||||||||||
| I. Measured covariates | ||||||||||||
| A. Sociodemographic determinants | ||||||||||||
| A-1. Related to the baby | ||||||||||||
| Date of birth | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ |
| Sex | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | |||
| Gestational age at delivery | Χ | Χ | Χ | Χ | Χ | Χ | ||||||
| Birth weight | Χ | Χ | Χ | |||||||||
| Mode of delivery | Χ | Χ | ||||||||||
| A-2. Related to the mother | ||||||||||||
| Hip grant | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ |
| Age | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ |
| Weight at booking | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | |
| Height | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | |||
| Ethnic group | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ |
| Parity | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ |
| Marital status | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ |
| Social class | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ |
| B. Medical risks of the current pregnancy and before pregnancy | ||||||||||||
| Diabetes | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | |
| Hypertension | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | |
| Infection | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | |||
| Congenital anomalies | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | |||
| Induction of labour | Χ | Χ | Χ | |||||||||
| Duration of labour | Χ | Χ | Χ | |||||||||
| C. Medical risks related to previous pregnancies | ||||||||||||
| Previous spontaneous abortions | Χ | Χ | Χ | |||||||||
| Previous stillbirths | Χ | Χ | Χ | |||||||||
| Previous neonatal deaths | Χ | Χ | Χ | |||||||||
| D. Environmental and behavioural risks | ||||||||||||
| Income domain of the SIMD | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ |
| Urban/rural status of the area of residence | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ |
| Booking status (gestational age at booking, booking before 25 weeks) | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | ||
| Smoking status (before and during this pregnancy) | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | |
| Typical weekly alcohol consumption (before and during this pregnancy) | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ |
| Drug misuse during this pregnancy | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ | Χ |
| II. Unmeasured covariates | ||||||||||||
| Maternal weight gain | ||||||||||||
| Maternal nutrition | ||||||||||||
| Maternal education | ||||||||||||
| Maternal exposure to stress | ||||||||||||
| Maternal physical activity | ||||||||||||
| Exposure to toxic substances | ||||||||||||
| Birth interval | ||||||||||||
| History of preterm birth | ||||||||||||
| Statistical methods | ||||||||||||
| Multilevel linear regression | Χ | Χ | Χ | Χ | ||||||||
| Multilevel binomial logistic regression | Χ | Χ | Χ | Χ | Χ | |||||||
| Multilevel multinomial logistic regression | Χ | Χ | Χ | |||||||||
Χ: variables which will be considered for adjustment in the statistical analysis.
SIMD, Scottish Index of Multiple Deprivation.