Event per 100 000 patients (95% CI) | 1 year | Difference | 5 years | Difference | ||||||
---|---|---|---|---|---|---|---|---|---|---|
NMF | PS | No Tx | PS-NMF | No Tx-NMF | NMF | PS | No Tx | PS-NMF | No Tx-NMF | |
Ischaemic heart disease | 1186 (861 to 1732) | 1303 (901 to 1995) | 1573 (991 to 2526) | 117 (39 to 271) | 387 (129 to 802) | 5834 (4339 to 8526) | 6494 (4540 to 9979) | 7686 (4841 to 12 202) | 660 (200 to 1678) | 1852 (528 to 3765) |
Ischaemic stroke | 269 (199 to 393) | 297 (209 to 454) | 359 (232 to 580) | 28 (9 to 63) | 90 (32 to 188) | 1348 (998 to 1973) | 1514 (1053 to 2361) | 1805 (1123 to 2901) | 167 (54 to 439) | 457 (132 to 959) |
Haemorrhagic stroke | 105 (90 to 127) | 114 (95 to 142) | 136 (107 to 179) | 9 (4 to 17) | 31 (16 to 52) | 427 (368 to 534) | 477 (401 to 624) | 571 (447 to 750) | 50 (25 to 99) | 143 (75 to 222) |
Liver cirrhosis | 203 (150 to 287) | 244 (175 to 364) | 352 (234 to 533) | 41 (22 to 83) | 148 (83 to 250) | 885 (697 to 1260) | 1092 (851 to 1623) | 1500 (1093 to 2171) | 207 (114 to 407) | 615 (368 to 932) |
Pancreatitis | 229 (156 to 365) | 288 (190 to 486) | 451 (274 to 766) | 59 (28 to 130) | 222 (115 to 408) | 778 (610 to 1169) | 960 (735 to 1524) | 1358 (961 to 2135) | 182 (91 to 394) | 580 (336 to 986) |
Lower respiratory tract infections | 918 (687 to 700) | 968 (689 to 706) | 1109 (713 to 732) | 50 (−3 to 10) | 192 (23 to 34) | 2917 (2627 to 2903) | 3256 (2882 to 3266) | 3843 (3319 to 3551) | 339 (135 to 496) | 926 (543 to 809) |
Transport injuries | 548 (524 to 590) | 720 (681 to 778) | 1109 (1097 to 1119) | 172 (124 to 224) | 560 (518 to 584) | 2515 (2333 to 2980) | 3505 (3248 to 4166) | 5318 (5070 to 5488) | 990 (619 to 1513) | 2803 (2309 to 2979) |
Injuries other than transport | 3091 (1870 to 5174) | 3911 (2336 to 6566) | 5734 (3339 to 9596) | 820 (418 to 1486) | 2643 (1457 to 4460) | 13 657(9089 to 22 419) | 18 241 (12 125 to 30 474) | 26 483 (16 680 to 41 824) | 4584 (2411 to 9126) | 12 826 (7107 to 20 140) |
Deaths from serious events | 260 (200 to 442) | 348 (255 to 621) | 493 (332 to 939) | 88 (52 to 192) | 233 (131 to 503) | 1273 (1021 to 2013) | 1491 (1171 to 2461) | 1892 (1393 to 3216) | 219 (117 to 518) | 620 (348 to 1226) |
Deaths from short-term events | 185 (170 to 215) | 225 (203 to 266) | 270 (237 to 324) | 41 (29 to 53) | 86 (65 to 110) | 1013 (931 to 1149) | 1103 (1010 to 1279) | 1257 (1122 to 1458) | 90 (51 to 162) | 245 (161 to 339) |
Total number of events | 6549 (5074 to 8524) | 7845 (5962 to 10 381) | 10 823(7962 to 14 489) | 1296 (788 to 2004) | 4273 (2842 to 5950) | 28 361 (23 817 to 38 177) | 35 540 (29 699 to 49 069) | 48 563 (38 527 to 64 212) | 7179 (4244 to 12 654) | 20 202 (13 942 to 27 243) |
Total number of deaths | 445 (384 to 628) | 573 (479 to 853) | 763 (599 to 1212) | 129 (87 to 235) | 319 (212 to 585) | 2285 (2021 to 3027) | 2594 (2273 to 3595) | 3149 (2634 to 4466) | 309 (181 to 641) | 864 (558 to 1469) |
NMF, nalmefene plus psychosocial support; No Tx, ‘No treatment’ arm; PS, psychosocial support alone.