Table 3

Prescribed medication and clinical diagnoses recorded at baseline in CPRD validation cohort and QResearch comparison cohort

CPRD men (%)CPRD women (%)QResearch men (%)QResearch women (%)
Prescribed medication
 Anticoagulants15 955 (1.0)13 077 (0.8)27 024 (0.8)22 178 (0.6)
 Antidepressants101 553 (6.4)235 797 (14.0)178 532 (5.4)398 018 (11.5)
 Antipsychotics33 884 (2.1)79 514 (4.7)47 464 (1.4)92 307 (2.7)
 Antiplatelets97 475 (6.1)92 816 (5.5)160 910 (4.9)153 405 (4.4)
 Oral NSAIDs246 515 (15.5)346 416 (20.6)396 026 (12.0)556 644 (16.1)
 Tamoxifenn/a9231 (0.5)n/a18 343 (0.5)
 Oestrogen only hormone replacement therapyn/a119 373 (7.1)n/a208 333 (6.0)
 Oral corticosteroids45 597 (2.9)71 352 (4.2)54 354 (1.6)88 205 (2.6)
 Oral contraceptive pilln/a174 287 (10.4)n/a332 696 (9.6)
Recorded diagnoses
 Congestive cardiac failure15 836 (1.0)19 707 (1.2)24 965 (0.8)28 852 (0.8)
 Atrial fibrillation20 125 (1.3)20 102 (1.2)33 499 (1.0)32 580 (0.9)
 Coronary heart disease80 377 (5.1)57 703 (3.4)130 220 (3.9)88 606 (2.6)
 Cardiovascular disease101 430 (6.4)83 167 (4.9)165 495 (5.0)130 214 (3.8)
 Peripheral vascular disease17 029 (1.1)13 101 (0.8)25 004 (0.8)17 078 (0.5)
 Venous thromboembolism15 072 (0.9)23 090 (1.4)27 086 (0.8)40 813 (1.2)
 Rheumatoid or SLE7455 (0.5)19 010 (1.1)21 453 (0.6)48 447 (1.4)
 Rheumatoid arthritis7243 (0.5)17 468 (1.0)21 142 (0.6)45 542 (1.3)
 SLE228 (0.0)1756 (0.1)351 (0.0)3374 (0.1)
 Type 1 diabetes6238 (0.4)4924 (0.3)12 029 (0.4)9612 (0.3)
 Type 2 diabetes51 634 (3.2)43 271 (2.6)95 401 (2.9)79 654 (2.3)
 Treated hypertension123 584 (7.8)161 709 (9.6)210 516 (6.4)267 076 (7.7)
 Chronic renal disease3968 (0.2)4082 (0.2)8550 (0.3)8995 (0.3)
 Moderate/severe kidney failure14 107 (0.9)9500 (0.6)30 407 (0.9)21 509 (0.6)
 Severe kidney failure1603 (0.1)1125 (0.1)3641 (0.1)2672 (0.1)
 Renal stones13 415 (0.8)6443 (0.4)37 422 (1.1)29 204 (0.8)
 Inflammatory bowel disease8962 (0.6)10 208 (0.6)17 762 (0.5)19 502 (0.6)
 Dementia6686 (0.4)16 634 (1.0)12 872 (0.4)30 497 (0.9)
 Parkinson’s disease4546 (0.3)4676 (0.3)6830 (0.2)6611 (0.2)
 Epilepsy or anticonvulsants47 170 (3.0)71 171 (4.2)56 516 (1.7)61 561 (1.8)
 Cancer26 866 (1.7)43 908 (2.6)51 649 (1.6)79 326 (2.3)
 Liver disease3959 (0.2)2893 (0.2)9947 (0.3)6410 (0.2)
 Chronic liver disease or pancreatitis5521 (0.3)4051 (0.2)13 069 (0.4)8729 (0.3)
 Oesophageal varices469 (0.0)340 (0.0)1626 (0.0)1388 (0.0)
 Prior haemorrhage97 562 (6.1)79 765 (4.7)203 278 (6.2)147 533 (4.3)
 Malabsorption7343 (0.5)9375 (0.6)21 042 (0.6)26 002 (0.8)
 Endocrine diseases3082 (0.2)14 097 (0.8)6026 (0.2)27 731 (0.8)
 COPD24 029 (1.5)20 737 (1.2)41 281 (1.2)34 785 (1.0)
 Asthma or COPD142 974 (9.0)169 503 (10.1)273 768 (8.3)310 027 (9.0)
 History of falls28 878 (1.8)61 905 (3.7)34 584 (1.0)67 465 (2.0)
 Prior fracture24 265 (1.5)45 752 (2.7)62 092 (1.9)89 000 (2.6)
 Varicose vein surgery18 979 (1.2)47 012 (2.8)35 651 (1.1)85 602 (2.5)
 Emergency admissions or hip operation3483 (0.2)5266 (0.3)3335 (0.1)5508 (0.2)
  • CPRD, Clinical Research Data Link; NSAIDS, non-steroidal anti-inflammatory drugs; COPD, chronic obstructive pulmonary disease.