Alcohol intake | N | Sperm concentration*† (million/mL) | Total sperm count*† (million) | Morphology†‡ (%) | N | Testosterone§¶ (nmol/L) | SHBG§¶ (nmol/L) | Free testosterone§¶ (pmol/L) | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Β | 95% CI | β | 95% CI | β | 95% CI | % | 95% CI | % | 95% CI | % | 95% CI | |||
Units in a typical week, N=553 | Units the week preceding the visit, N=1194 | |||||||||||||
0 | 121 | −0.32 | −0.62 to −0.03 | −0.42 | −0.86 to 0.01 | −0.21 | −0.54 to 0.12 | 242 | −2.7 | −8.5 to 3.5 | −0.6 | −8.6 to 6.9 | −3.3 | −9.1 to 2.6 |
1–5 | 92 | Reference | Reference | Reference | 193 | Reference | Reference | Reference | ||||||
6–10 | 71 | −0.04 | −0.38 to 0.3 | −0.06 | −0.56 to 0.45 | −0.12 | −0.49 to 0.26 | 154 | 3.3 | −3.6 to 10.6 | −3.0 | −10.6 to 5.2 | 5.5 | −1.4 to 12.9 |
11–15 | 80 | −0.21 | −0.54 to 0.12 | −0.29 | −0.77 to 0.20 | −0.19 | −0.56 to 0.18 | 160 | 2.0 | −4.9 to 9.2 | −3.1 | −10.6 to 5.1 | 3.6 | −3.1 to 10.7 |
16–20 | 62 | −0.03 | −0.39 to 0.33 | −0.18 | −0.70 to 0.34 | −0.09 | −0.46 to 0.29 | 130 | 3.0 | −4.2 to 10.8 | −2.1 | −10.1 to 6.7 | 4.3 | −3.0 to 12.0 |
21–25 | 45 | 0.25 | −0.15 to 0.65 | 0.07 | −0.52 to 0.65 | −0.13 | −0.55 to 0.29 | 92 | 7.3 | −1.1 to 16.4 | −0.2 | −9.4 to 9.9 | 7.9 | −0.3 to 16.9 |
26–30 | 25 | −0.35 | −0.83 to 0.14 | −0.65 | −1.37 to 0.08 | −0.19 | −0.71 to 0.34 | 71 | 1.0 | −7.7 to 10.4 | −9.0 | −18.1 to 1.1 | 5.9 | −3.1 to 15.5 |
31–35 | 14 | −0.29 | −0.92 to 0.33 | −0.60 | −1.51 to 0.31 | −0.56 | −1.19 to 0.06 | 47 | 6.1 | −4.5 to 17.8 | −9.8 | −20.3 to 2.1 | 11.9 | 0.8 to 23.9 |
36–40 | 11 | −0.33 | −1.02 to 0.35 | −0.73 | −1.73 to 0.28 | −0.54 | −1.20 to 0.13 | 28 | 9.1 | −4.2 to 17.8 | −9.3 | −22.2 to 5.7 | 16.0 | 2.1 to 31.7 |
>40 | 21 | −0.39 | −0.92 to 0.14 | −0.54 | −1.32 to 0.23 | −0.46 | −0.99 to 0.08 | 66 | 10.6 | 0.8 to 21.3 | −12.0 | −21.1 to −1.9 | 19.5 | 9.2 to 30.9 |
p trend** | 0.02 | 0.01 | 0.02 | 0.01 | <0.01 | <0.01 | ||||||||
Number of binge episodes during the past 30 days†† | ||||||||||||||
0 | 174 | Reference | Reference | Reference | 171 | Reference | Reference | Reference | ||||||
1–2 | 248 | −0.01 | −0.23 to 0.22 | 0.15 | −0.18 to 0.48 | 0.07 | −0.16 to 0.31 | 246 | 4.0 | −2.5 to 10.8 | 7.9 | 0.1 to 16.4 | 1.0 | −5.2 to 7.6 |
3–5 | 407 | 0.08 | −0.13 to 0.29 | 0.26 | −0.05 to 0.56 | 0.10 | −0.12 to 0.31 | 401 | 6.2 | 0.1 to 12.6 | 4.1 | −2.9 to 11.6 | 6.1 | 0.1 to 12.4 |
6–9 | 253 | 0.00 | −0.23 to 0.23 | 0.08 | −0.26 to 0.41 | −0.04 | −0.28 to 0.19 | 252 | 8.4 | 1.6 to 15.6 | 1.1 | −6.7 to 9.2 | 10.2 | 3.4 to 17.5 |
>9 | 88 | −0.02 | −0.32 to 0.29 | 0.03 | −0.41 to 0.47 | −0.22 | −0.52 to 0.08 | 89 | 13.0 | 3.8 to 23.1 | −2.9 | −12.1 to 7.5 | 17.2 | 7.8 to 27.6 |
p trend** | 0.93 | 0.87 | 0.16 | <0.01 | 0.31 | 0.01 |
*Adjusted for period of abstinence, smoking and body mass index (BMI) categorised according to table 2 (sperm morphology not adjusted for period of abstinence).
†Transformed by cubic root.
‡Counted for 904 men of whom 397 stated that last weeks alcohol intake represented a typical week.
§Adjusted to a time at 8.00, BMI and smoking.
¶Transformed by the use of natural logarithm and back transformed giving the percentages change.
**Test for trend was performed by inserting the categorical alcohol variable into the model assuming the association to be linear with 1–5 units weekly as reference and 0 units excluded.
††Binging defined as alcohol intake for more than 5 units on one occasion.