Performance of each score for predicting the relevant outcome in the CPRD validation cohort. The cut-off is the threshold of predicted risk for the top decile in the CPRD cohort
| Score | Outcome | Duration | Cut-off (%) for top decile predicted risk | Sensitivity (%) | Specificity (%) | Observed risk (%) |
|---|---|---|---|---|---|---|
| QDiabetes | Type 2 diabetes | 10-year risk | 13.0 | 44.8 | 91.0 | 20.8 |
| QStroke | Ischaemic stroke | 10-year risk | 10.5 | 54.7 | 90.8 | 16.1 |
| QRISK2 | Cardiovascular disease | 10-year risk | 20.7 | 49.9 | 91.9 | 31.8 |
| QThrombosis | Venous thromboembolism | 5-year risk | 1.5 | 36.2 | 90.1 | 2.6 |
| QKidney | Moderate-severe kidney failure | 5-year risk | 6.3 | 59.1 | 90.5 | 6.9 |
| QKidney | Severe kidney failure | 5-year risk | 0.4 | 58.5 | 90.0 | 0.7 |
| QBleed | Upper GI bleed | 5-year risk | 1.6 | 38.0 | 90.2 | 3.5 |
| QBleed | Intracranial bleed | 5-year risk | 0.9 | 44.2 | 90.1 | 1.6 |
| QFracture | Fractured neck of femur | 10-year risk | 3.7 | 66.5 | 90.4 | 9.4 |
| QFracture | Osteoporotic fracture | 10-year risk | 7.8 | 49.6 | 90.5 | 13.1 |
CPRD, Clinical Research Data Link; GI, gastrointestinal.