Quality assessment of randomised controlled trials using tools adapted from the Delphi list
| Items | Explanation | Rating |
|---|---|---|
| Sequence generation | Is the method of sequence generation clearly reported? | Yes/no/unclear |
| Allocation concealment | Is treatment allocation concealment (using an opaque envelope, central allocation) performed? | Yes/no/unclear |
| Baseline characteristics | Are the groups similar at baseline regarding the most important prognostic factors? | Yes/no/unclear |
| Eligibility criteria | Are eligibility criteria clearly specified? | Yes/no/unclear |
| Blindness to outcome assessor | Is the outcome (mortality) assessor blinded? | Yes/no/unclear |
| Blindness to care provider | Is the allocation unknown to the treating physician? | Yes/no/unclear |
| Blindness to patient | Is the patient blinded? | Yes/no/unclear |
| Point estimate and variability | Are the point estimate and variability reported for the outcome measure? | Yes/no/unclear |
| Intention-to-treat | Does the analysis include intention to treat analysis? | Yes/no/unclear |