Table 1

Visit schedule

VisitDay 1Day 2Day 3Day 4Day 5Day 6Day 7Day 8–28
Informed consent (patient consent/PerLR/ProLR/retrospective patient information)Retrospective consent (PerLR/ProLR) will be obtained at the first available opportunity. Retrospective patient consent will be obtained when the patient has recovered
Inclusion/exclusion criteriaX
Study drug administration (study drug 1 and 2)Study drug 1 (vasopressin/noradrenaline) continued until shock resolved. If BP was still low, study drug 2 (hydrocortisone/placebo) administered as described in this protocol
Blood and urine samplingXXXX
Daily collection of clinical dataXXXXXXXX
Final visitOn the day of discharge from the hospital
  • BP, blood pressure; PerLR, personal legal representative; ProLR, professional legal representative.