Table 2

Associations between nutrients and AD biomarkers

AVGIPLLTLMFGPCCPFC
FDG glucose metabolism
 β-caroteneβ0.31a0.25c0.33a0.31a0.32a0.27c
SE0.0010.0010.0010.0010.0010.001
 Folateβ0.35b0.33a0.31a0.31a0.36b0.27c
SE0.0010.0010.0010.0010.0010.001
 Saturated fatsβ−0.20c−0.16−0.15−0.24c−0.13−0.16
SE0.0060.0060.0070.0070.0060.005
PiB retention
 Vitamin B12β−0.32a−0.37b−0.29a−0.33a−0.37a−0.27c
SE0.0060.010.0090.0080.0010.008
 Vitamin Dβ−0.26c−0.21−0.28a−0.13−0.28a−0.27c
SE0.0060.0090.0090.0070.0060.007
 ω-3 PUFAβ−0.18c−0.28a−0.07−0.24c−0.09−0.16
SE0.010.040.040.010.030.01
 ω-3 PUFA EPAβ−0.33a−0.37b−0.32a−0.20−0.31a−0.28c
SE0.320.490.470.400.420.39
  • Standardised β and SE estimates from linear regression using age-residual nutrients and caloric intake-residual nutrients from food sources.

  • ap≤0.05, bp≤0.01, cp=0.06–0.10.

  • AVG, average cortical ROI; EPA, eicosapentaenoic acid 20 : 4; FDG, 18F-fluorodeoxyglucose; IPL, inferior parietal lobe; LTL, lateral temporal lobe; MFG, medial frontal gyrus; PUFA, polyunsaturated fatty acids; PCC, posterior cingulate cortex; PFC, prefrontal cortex.