Table 3

Risk of PHN in patients with herpes zoster

CountryAuthorStudy designDefinition of PHN*YearPHN casesAgeRisk of PHN (%)
USARagozzinoMedical records database in MinnesotaPhysician diagnosis1945–195955All ages9.3
USAGalilAdministrative claims database confirmed by medical records in MassachusettsPain persisted for ≥60 days from medical records1990–199268All ages7.9
USAOxmanZostavax trial in the controlPain ≥3 score for ≥90 days1998–200180≥60 years14.0
USAYawnRetrospective population-based study confirmed by medical records in MinnesotaPain persisted for ≥90 days from medical records1996–2001171≥22 years10.0
USAThyregodProspective cohort study in CaliforniaPain persisted for ≥180 days1999–200330≥50 years31.9
USAKlompasAdministrative claims database confirmed by medical records in MassachusettsPain persisted for ≥30 days and required pain medication from medical records2008237≥20 years12.2
USARimlandAtlanta Veterans Affairs claims database confirmed by medical recordsPhysician diagnosis from medical charts2000–2007205All ages19.6
USAKatzProspective cohort study in New YorkPain persisted for ≥120 daysNA20≥18 years19.6
CanadaDroletProspective cohort study, recruited by 83 physicians throughout countryPain ≥3 score for ≥90 days2005–200656≥50 years22.5
UKHope-SimpsonProspective population-based study in CirencesterPhysician diagnosis1947–196246All ages14.3
UKScottProspective cohort studyPain persisted for ≥90 daysNA45All ages27.4
UKJungProspective cohort study (combined two trials)Pain persisted for ≥120 daysNA114≥15 years12.8
UKScottProspective cohort study in East LondonPain persisted for ≥90 daysNA9All ages13.4
UKCoenProspective cohort study, recruited by GPsPain ≥3 score for ≥90 days1998–200124All ages9.0
UKGauthierGPRD in the UKPhysician diagnosis or pain medication at 90 days from medical records2000–2006415≥50 years13.7
FranceChidiacProspective sentinel surveillancePhysician diagnosis1997–1998935All ages10.3
FranceCzernichowRetrospective population-based survey from GPsPain persisted for ≥30 days and required treatment from medical records1998111All ages18.4
FranceMickRetrospective population-based survey from GPs, dermatologists and neurologistsPain persisted for ≥90 days from medical records2005227≥50 years32.5
FranceBouhassiraProspective cohort study, recruited by GPsPain persisted for ≥90 days2007–2008127≥50 years11.6
GermanyMeisterRetrospective population-based survey from GPs, dermatologists and specialistsPain persisted for ≥30 days and physician diagnosisNA131≥50 years20.6
GermanySchiffner-RoheNational Statutory Health Insurance claims databasePain persisted for ≥90 days and diagnosis or pain medication from ICD-102004NA≥50 years6.9
GermanyWeinkeTelephone survey of patients, previous HZ diagnosis in 5 yearsPain persisted for ≥90 days200832≥50 years11.4
GermanyUltschNational Statutory Health Insurance claims databasePain persisted for ≥90 days and diagnosis or pain medication from ICD-102004–200918 160All ages4.5
The NetherlandsOpsteltenHuisartsen Netwerk Utrecht database in six locationsPain persisted for ≥90 days and required treatment from medical records1994–199922All ages2.6
The NetherlandsOpsteltenProspective cohort study, recruited by GPs (PINE trial)Pain ≥3 score for ≥90 days2001–200446≥50 years7.1
The NetherlandsPierikPopulation-based GPs database in AlmerePhysician diagnosis from medical codes2004–2008195All ages5.8
SpainCebrian-CuencaProspective cohort study, recruited by 25 GPs in ValenciaPain persisted for ≥90 days2006–200719≥14 years14.5
SpainSicras MainarMedical records from six primary care and one hospitalPhysician diagnosis from medical records2007–2010228≥30 years15.1
Italydi Luzio PaparattiRetrospective population-based survey from GPsPain persisted for ≥30 days from medical records1995275≥15 years19.6
ItalyVolpiProspective cohort study, recruited by dermatologistsPain ≥3 score for ≥180 days200170NA32.0
ItalyParrutiProspective cohort study, recruited from GPs and hospitals in PescaraPain persisted for ≥90 days2006–2008130NA30.0
ItalyGialloretiNational primary care database (Societa Italiana Medici Generici)Pain persisted for ≥90 days and diagnosis or pain medication from ICD-92003–2005350≥50 years6.2
ItalyBricoutProspective cohort study, recruited from GPsPain persisted for ≥90 days2009–201085≥50 years20.6
IcelandHelgasonProspective population-based studyPhysician diagnosis at 90 days1990–199528All ages7.2
6 European countriesLukasTelephone survey, previous 5 yearsPain persisted for ≥90 days2008––2009131≥50 years13.0
IsraelWeitzmanMaccabi Healthcare Services claims databaseICD-9 code and healthcare service code2006–20101508All ages5.2
Saudi ArabiaAlaklobyMedical record database from the dermatology clinicPhysician diagnosis1988–200621≥18 years14.9
AustraliaSteinNational GP database (Bettering the Evaluation of Care and Health)Physician diagnosis from medical codes2000–200657≥50 years15.0
TaiwanJihTaiwan National Health Insurance claims databasePain persisted for ≥90 days and diagnosis or pain medication from ICD-92000–20062944All ages8.6
TaiwanTsaiProspective cohort study in five centresPain ≥3 score for ≥90 days2008–200931≥50 years20.7
JapanKurokawaProspective cohort study in hospitals and clinics in HyogoPain persisted for ≥90 daysNA37≥20 years26.2
JapanKurokawaProspective cohort study in hospitals and clinics in HyogoPain persisted for ≥90 days2001–200378All ages24.7
JapanKanbayashiRetrospective cohort study in pain treatment hospitalPain persisted for ≥90 days2008–201038NA52.0
South KoreaRoRetrospective, dermatology department hospitalNA2007–2011826NA39.4
South KoreaSongProspective cohort study in clinicsPain ≥3 score for ≥90 days2009–201058≥50 years38.4
South KoreaChoProspective cohort study in clinicsPain ≥3 score for ≥90 days2010–201219≥18 years6.2
ThailandTunsuriyawongRetrospective study of medical records at hospitalPhysician diagnosis from medical record1995–200067All ages16.8
ThailandAunhachokeProspective cohort study, recruited by GPsPain persisted for ≥90 days2007–200835≥50 years19.4
SingaporeGohProspective cohort study in dermatology clinicPain persisted for ≥90 days1994–199546All ages28.0
IndiaChaudharyNANANA33NA14.3
IndiaAbdul LatheefNANANA21All ages10.2
ArgentinaVujacichMedical record database from ID reference centrePain persisted for ≥60 days and diagnosis from medical records2000–200539All ages12.9
ArgentinaVujacichProspective cohort study, recruited by GPsPain ≥3 score for ≥90 daysNA11≥50 years11.5
  • *For studies that used multiple definitions of PHN, we present results based on the definition that used at least 90 days of persistent pain.

  • GP, general practitioner; GPRD, general practice research database; HZ, herpes zoster; ICD, International Classification of Diseases; PHN, postherpetic neuralgia.