Characteristics of the patient population according to different morphology
| Group 1 (n=218) | Group 2 (n=27) | Group 3 (n=69) | Group 4 (n=16) | Group 5 (n=53) | p Value | |
|---|---|---|---|---|---|---|
| Clinical and demographic | ||||||
| Age (years) | 50±17 | 58±14 | 49±18 | 52±14 | 51±14 | 0.13 |
| Male sex, n (%) | 126 (56) | 21 (81) | 37 (54) | 11 (72) | 32 (57) | 0.24 |
| NYHA III-IV, n (%) | 28 (13) | 0 (0) | 7 (10) | 2 (13) | 8 (15) | 0.33 |
| Genotype on 173 patients, n (%) | 53 (55) | 5 (38) | 12 (39) | 2 (29) | 12 (48) | 0.37 |
| Echocardiography | ||||||
| IVS (mm) | 19.7±5.2 | 16.2±3.3 | 14.9±4.1 | 12.6±2.1 | 15.4±3.4 | <0.001* |
| PW (mm) | 11.9±2.9 | 11.4±2.0 | 13.8±3.4 | 10.7±2.5 | 11.2±2.4 | <0.001* |
| LVEF (%) | 70±7 | 69±6 | 68±9 | 66±6 | 69±9 | 0.19 |
| LV gradient >30 mm Hg, n (%) | 87 (40) | 8 (30) | 17 (25) | 3 (19) | 19 (36) | 0.010† |
| E wave (cm/s) | 82±26 | 88±28 | 85±27 | 70±12 | 91±31 | 0.07† |
| E/A | 1.3±0.59 | 1.1±0.46 | 1.33±0.62 | 1.5±0.55 | 1.22±0.63 | 0.19 |
| E/A>2, n (%) | 21 (10) | 1 (4) | 9 (15) | 3 (19) | 3 (6) | 0.34 |
| Deceleration time (ms) | 212±62 | 213±47 | 207±77 | 166±34 | 213±64 | 0.09 |
| Restrictive pattern (n, %) | 7 (3) | 0 (0) | 4 (5) | 1 (6) | 3 (6) | 0.53‡ |
| E′ (cm/s) | 7.9±3.3 | 8.1±2.6 | 8.4±3.7 | 8.7±3.5 | 8.3±3.7 | 0.82* |
| E′<12 cm/s (n, %) | 160 (86) | 23 (88) | 44 (79) | 12 (86) | 39 (81) | 0.65* |
| E/E′ | 12.3±7.9 | 12.1±6.1 | 12.7±9.5 | 9.4±4.0 | 12.7±7.9 | 0.71* |
| LAVi mL/m2 | 42.4±19.1 | 36.2±10.5 | 34.7±14.7 | 38.6±13.6 | 39.1±24.5 | 0.03* |
| LAVi>40 mL/m2, n (%) | 102 (47) | 9 (33) | 22 (32) | 6 (37) | 17 (32) | 0.09* |
| Moderate-to-severe MR | 15 (7) | 2 (7) | 3 (4) | 1 (6) | 3 (6) | 0.96‡ |
| RV dysfunction, n (%) | 11 (5) | 0 (0) | 3 (0) | 0 (0) | 3 (6) | 0.19‡ |
| RVSP mm Hg | 33±11 | 28±7 | 30±9 | 35±11 | 30±9 | 0.2* |
| RAVi (mL/m2) | 21.7±8.9 | 23.8±9.9 | 20.4±9.3 | 23.6±8.8 | 22.1±7.6 | 0.43 |
Group 1: septal reverse; group 2: septal sigmoid; group 3: symmetric; group 4: apical; group 5: undefined.
p Value indicates the difference between subgroups according to morphology.
*All the morphology subgroups are significantly different (p<0.05) in comparison with controls.
†Four morphology subgroups are significantly different (p<0.05) in comparison with controls.
‡Three morphology subgroups are significantly different (p<0.05) in comparison with controls.
IVS, interventricular septum; LAVi, left atrium volume index; LV, left ventricle; LVEF, left ventricle ejection fraction, MR, mitral regurgitation; PW, posterior wall; RAVi, right atrium volume index; RV, right ventricle; RVSP, right ventricle systolic pressure.