HRs of coronary events in Framingham and Korean studies in men and women
| Men | Women | |||||
|---|---|---|---|---|---|---|
| Framingham Heart Study | Korean Heart Study | p Value | Framingham Heart Study | Korean Heart Study | p Value | |
| Age (year) | 1.05 (1.04–1.06) | 1.07 (1.06–1.07) | 0.0040 | 1.04 (1.03–1.06) | 1,09 (1.08–1.11) | <0.0001 |
| Blood pressure (mm Hg) | ||||||
| Optimal+normal | 1.00 | 1.00 | 1.00 | 1.00 | ||
| High normal | 1.32 (0.98–1.78) | 1.28 (1.13–1.45) | 0.8352 | 1.34 (0.88–2.05) | 1.40 (1.07–1.83) | 0.8659 |
| Stage 1 | 1.73 (1.32–2.26) | 1.62 (1.46–1.81) | 0.6668 | 1.75 (1.21–2.54) | 1.65 (1.31–2.09) | 0.7907 |
| Stage 2–4 | 1.92 (1.36–2.24) | 2.10 (1.83–2.40) | 0.6409 | 2.19 (1.46–3.27) | 2.61 (2.04–3.34) | 0.4701 |
| LDL-cholesterol (mg/dL) | ||||||
| <130 | 1.00 | 1.00 | 1.00 | 1.00 | ||
| 130–159 | 1.19 (0.91–1.54) | 1.56 (1.42–1.73) | 0.0611 | 1.24 (0.84–1.81) | 1.24 (1.01–1.53) | 0.9931 |
| ≥160 | 1.74 (1.36–2.34) | 2.34 (2.09–2.62) | 0.0326 | 1.68 (1.17–2.40) | 1.43 (1.14–1.79) | 0.4602 |
| HDL-cholesterol (mg/dL) | ||||||
| <35 | 1.46 (1.15–1.85) | 1.68 (1.48–1.90) | 0.3092 | 2.08 (1.33–3.25) | 1.25 (0.85–1.84) | 0.0911 |
| 35–59 | 1.00 | 1.00 | 1.00 | 1.00 | ||
| ≥60 | 0.61 (0.41–0.91) | 0.66 (0.57–0.78) | 0.7080 | 0.64 (0.47–0.87) | 0.72 (0.58–0.89) | 0.5517 |
| Smoking (yes/no) | 1.71 (1.39–2.10) | 1.89 (1.72–2.07) | 0.3917 | 1.49 (1.13–1.97) | 1.95 (1.40–2.72) | 0.2230 |
| Diabetes (yes/no) | 1.47 (1.04–2.08) | 1.71 (1.53–1.91) | 0.4182 | 1.80 (1.18–2.74) | 1.96 (1.57–2.45) | 0.7276 |
The regression coefficients for the Framingham and Korean cohorts were compared using a two-tailed z statistic, where z=(b[F]−b[C])/SE.
The SE is the standard error of the difference in coefficients, and SE=(SE[F]2+SE[K]2)1/2.
Source: Wilson et al.1,1
HDL, high-density lipoprotein; LDL, low-density lipoprotein.