Medical conditions in which corticosteroids were tested, with number of studies, number of participants and number of adverse effects
| Disease | Hospitalised | Ambulant | Total | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Number of studies | Number of participants | Number of adverse effects | Number of studies | Number of participants | Number of adverse effects | Number of participants | |||||
| Ster | Plac | Ster | Plac | Ster | Plac | Ster | Plac | Sum | |||
| Traumatic injury (brain, spinal cord, multiple) | 9 | 5821 | 5790 | 95 | 75 | 0 | – | – | – | – | 11 611 |
| Meningitis | 18 | 1589 | 1549 | 110 | 91 | 0 | – | – | – | – | 3138 |
| Sepsis/septic shock | 7 | 482 | 449 | 32 | 28 | 0 | – | – | – | – | 931 |
| Bronchopulmonary dysplasia | 21 | 1508 | 1487 | 155 | 85 | 0 | – | – | – | – | 2995 |
| Liver diseases* | 4 | 150 | 114 | 26 | 15 | 3 | 705 | 709 | 5 | 1 | 1678 |
| Lung diseases % | 20 | 1149 | 1105 | 8 | 3 | 7 | 537 | 544 | 0 | 0 | 3335 |
| Rheumatoid arthritis | 0 | – | – | – | – | 5 | 283 | 279 | 1 | 2 | 562 |
| Miscellaneous† | 24 | 1743 | 1666 | 46 | 24 | 41 | 2806 | 2788 | 2 | 0 | 9003 |
| Sum | 103 | 12 442 | 12 160 | 472 | 321 | 56 | 4331 | 4320 | 8 | 3 | 33 253 |
Grouping by treatment level was based on statements in the reports and, if there was no indication of treatment level, on clinical judgement. Patients with traumatic injury, meningitis, sepsis/septic shock and bronchopulmonary dysplasia were defined as hospitalised.
*Hepatitis, liver cirrhosis, acute hepatic failure. % Asthma, ARDS, bronchiolitis, chronic obstructive pulmonary disease, pneumonia, tuberculosis, ventilator weaning.
†Miscellaneous diseases as stated in the original reports (number of studies in brackets): acute otitis media, adhesive capsulitis, allergic rhinitis, Alzheimer's disease, Behçet's syndrome, Bell's palsy (2), carpal tunnel syndrome, cerebral infarction, chronic fatigue syndrome, coronary artery bypass grafting (2), cysticercus granuloma with seizures, depression, Duchenne's muscular dystrophy, emesis (9), erysipelas, facial nerve paralysis (2), glaucoma, Grave's orbitopathy, Guillain-Barré syndrome (2), healthy postmenopausal women, Henoch Schonlein purpura (2), herpes zoster (3), IgA nephropathy, intracerebral haemorrhage (2), leprosy, lumbar disc surgery, migraine headaches, multiple sclerosis (3), myocardial infarction (2), postinfectious irritable bowel syndrome, preeclampsia, (pre)terminal cancer (2), aphthous stomatitis, sinonasal polyposis, sinusitis, Sjøgren's syndrome, Sydenham's Chorea in children, tetanus, tonsillectomy (2), tuberculous pericarditis in HIV, typhoid fever, urticaria, vestibular neuritis, withdrawal headache.
ARDS, acute respiratory distress syndrome; Plac, placebo; Ster, corticosteroids.