Table 3

Effects of epilepsy surgery on the discontinuation of antiepileptic drugs in 189 epilepsy patients

Drug− Ranks+ RanksTiesMcNemar or Wilcoxon test*Discontinuation rate
Phenobarbital711810.0707/37
Phenytoin233163<0.00123/61
Carbamazepine251163<0.00125/133
Valproic acid1631700.00416/46
Clonazepam621810.2896/12
Gabapentin1121760.02211/20
Lamotrigine254160<0.00125/62
Topiramate1341720.04913/20
Levetiracetam26151480.11826/54
Clobazam29101500.00329/58
All drugs921384<0.001*
  • The difference between postsurgery minus presurgery use of antiepileptic drugs is shown as the discontinuation of the drugs after surgery (negative ranks), starting new treatments after surgery (positive ranks) or unchanged treatments after surgery (ties). Thus ‘ties’ includes patients in whom the specific drugs were not changed and patients who were not using this drug.

  • *All analyses are results of the McNemar test, except the Wilcoxon test (z=−7.61).