Table 1

WelTel LTBI: outcomes, measures and methods of analysis

Outcome/variableHypothesisOutcome measureMethod of analysis
1. Primary outcome
Treatment completionIntervention>controlCompletes ≥80% of prescribed INH in 12 monthsχ2 test
2. Secondary outcomes
(a) AdherenceIntervention>controlMean (or median) number of doses takenT test or Kruskal-Wallis test
(b) 90% treatment completionIntervention>controlCompletes >90% of prescribed INH in 12 monthsχ2 test or Kruskal-Wallis test
(c) Time to treatment completionIntervention>controlTime to INH completionKaplan-Meier survival analysis
(d) Quality of lifeIntervention>controlSF12 PCS and MCS scorest test
3. Subgroup analyses
(a) Female vs maleFemales>malesRegression methods with appropriate interaction term
(b) AgeYounger>older
(c) Shared vs own phoneOwn phone>shared phone
(d) Foreign-bornNon-foreign-born>foreign-born
(e) Distance from clinic≤1>1 h
  • INH, isoniazid; LTBI, latent tuberculosis infection; MCS, mental composite score; PCS, physical composite score.