Table 1

Multivariate analysis for cardiovascular events with different degrees of adjustments (Cox regression analysis)

Model 1Model 2Model 3Model 4Model 5
Moderate fat content1.51 (0.99 to 2.29)1.44 (0.93 to 2.23)1.31 (0.84 to 2.05)1.30 (0.84 to 2.01)1.49 (0.99 to 2.26)
Severe fat content1.92 (1.32 to 2.80)**1.74 (1.16 to 2.63)**1.49 (0.97 to 2.30)1.43 (0.93 to 2.18)1.76 (1.21 to 2.56)**
Study group1.34 (0.98 to 1.85)1.29 (0.92 to 1.80)1.28 (0.92 to 1.78)
Age1.06 (1.03 to 1.09)***1.05 (1.02 to 1.08)**1.05 (1.02 to 1.08)**1.05 (1.02 to 1.07)**1.05 (1.02 to 1.08)**
Gender2.39 (1.71 to 3.34)*1.91 (1.34 to 2.71)***1.80 (1.26 to 2.57)**1.83 (1.29 to 2.60)**1.92 (1.36 to 2.72)***
LDL-cholesterol1.17 (0.99 to 1.39)1.15 (0.97 to 1.37)
Smoking (pack-years)1.02 (1.01 to 1.03)***1.02 (1.01 to 1.03)***1.02 (1.01 to 1.03)***1.02 (1.01 to 1.03)***
Alcohol consumption (group 1)0.93 (0.59 to 1.45)0.92 (0.59 to 1.44)
Alcohol consumption (group 2)0.84 (0.44 to 1.60)0.81 (0.42 to 1.54)
Systolic blood pressure1.01 (1.00 to 1.02)**1.01 (1.00 to 1.02)*1.01 (1.00 to 1.02)**1.01 (1.00 to 1.02)**
Body mass index0.99 (0.96 to 1.03)0.97 (0.93 to 1.01)
QUICKI0.12 (0.02 to 0.90)*0.16 (0.03 to 0.99)*
  • CVD event occurred in 13.5% of the participants with no fat in the liver (97/720), 24.2% (30/124) of participants having moderate liver fat content and 29.2% (42/144) of the participants having severe fatty liver. HRs with 95% CI with different degrees of adjustments are presented. Alcohol consumption was divided into groups (reference group: less than 1 g/week in men and women, group 1: less than 210 g/week in men and less than 140 g/week in women, group 2: more than 210 g/week in men and more than 140 g/week in women). Model 1: adjustment for study group, age and gender. Model 2: further adjustments for LDL-cholesterol, smoking, alcohol consumption, systolic blood pressure and body mass index. Model 3: further adjustment for QUICKI. Model 4: adjustments with statistically significant covariates. Model 5: adjustments with statistically significant covariates without QUICKI. *p<0.05,**p<0.01,***p<0.001.

  • CVD, cardiovascular disease; LDL, low-density lipoprotein; QUICKI, quantitative insulin sensitivity check index.