Follow-up and comparative study of liver function tests in controls and patients with Gilbert's syndrome treated with isotretinoin
| Case/variable | Gilbert's syndrome | Control | p Value* |
|---|---|---|---|
| Basal bilirubin levels | 1.78±0.65 | 0.50±0.22 | <0.001 |
| Bilirubin levels after 10 weeks | 1.03±0.18 | 0.52±0.27 | <0.001 |
| Bilirubin levels after 20 weeks | 1.38±0.54 | 0.48±0.26 | <0.001 |
| Basal AST levels | 22.1±5.1 | 21.6±14.7 | 0.14 |
| AST levels after 10 weeks | 23.8±5.4 | 21.4±7.8 | 0.11 |
| AST levels after 20 weeks | 21.5±7.1 | 21.4±7.6 | 0.95 |
| Basal ALT levels | 20±10.4 | 15.4±9.0 | 0.12 |
| ALT levels after 10 weeks | 21.1±7.9 | 15.8±6.6 | <0.05 |
| ALT levels after 20 weeks | 18.2±7.3 | 15.5±6.4 | 0.25 |
| Basal GGT levels | 18.1±9.9 | 14±4.7 | 0.35 |
| GGT levels after 10 weeks | 24±1.7 | 17.1±7.9 | 0.23 |
| GGT levels after 20 weeks | 17.1±4.5 | 18.4±8.5 | 0.79 |
*Mann–Whitney test.
ALT, alanine transaminase; AST, aspartate aminotransferase; GGT, γ-glutamyl transpeptidase.