Subpopulation of SIRS patients meeting definitions of acute kidney injury using multiple postoperative creatinine measurements
| All patients (n=4231)* | Patients with a preoperative eGFR ≥60 mL/min/1.73 m2 (n=3016) | Patients with a preoperative eGFR <60 mL/min/1.73 m2 (n=1215) | Statistical power to detect a 20% relative risk reduction (4200 patients)† | |
|---|---|---|---|---|
| AKI (a guideline definition) | 1386 (32.8%) | 935 (31.0%) | 451 (37.1%) | 99 |
| AKI for at least 2 days | 903 (21.3%) | 549 (18.2%) | 354 (29.1%) | 94 |
| AKI for at least 3 days | 575 (13.6%) | 324 (10.7%) | 251 (20.7%) | 78 |
*Number of SIRS patients with multiple postoperative creatinine data as of November 2013 (raw data). At the time of final analysis, we expect that over 4200 patients will meet the criteria for the primary AKI analysis.
†Two-tailed α 0.05, χ2 test, assumes that the incidence observed in all patients (n=4231) will be the incidence observed in the placebo group.
SIRS, steroids In caRdiac Surgery trial; eGFR, estimated-glomerular filtration rate.