Summary of regression analysis for biomarkers of exposure and effect of chlorpyrifos predicting average percentage of neurological symptoms over the entire study stratified by applicator status
| Explanatory variables | Unadjusted models | Adjusted models* | ||||
|---|---|---|---|---|---|---|
| B (se) | 95% CI | p Value | B (se) | 95% CI | p Value | |
| For non-applicators | ||||||
| Ln TCPy (mg/g Cr) (n=28) | 0.29 (0.76) | −1.26 to 1.84 | 0.71 | 0.57 (0.79) | −1.06 to 2.20 | 0.47 |
| Ln (Post-AChE/Pre-AChE) (n=21) | −1.25 (16.41) | −35.59 to 33.1 | 0.94 | −6.57 (18.80) | −43.64 to 33.50 | 0.73 |
| Ln (Post-BChE/Pre-BChE) (n=21) | 2.23 (7.04) | −12.51 to 16.98 | 0.76 | 2.50 (7.63) | −13.77 to 18.77 | 0.75 |
| For applicators | ||||||
| Ln TCPy (mg/g Cr) (n=42) | 4.56 (0.63) | 3.29 to 5.84 | <0.001 | 2.68 (0.93) | 0.78 to 4.57 | 0.007 |
| Ln (Post-AChE/Pre-AChE) (n=28) | −24.21 (12.79) | −50.50 to 2.09 | 0.07 | −11.60 (12.44) | −37.46 to 14.25 | 0.36 |
| Ln (Post-BChE/Pre-BChE) (n=29) | −14.52 (4.61) | −23.97 to −5.07 | 0.004 | −7.33(5.93) | −19.63 to 4.97 | 0.23 |
*Regression models adjusted for field stations, age, family monthly income, pesticide use at home and average number of hours of work in the field over the entire application season (for applicators only).
AChE, acetylcholinesterase; BChE, butyrylcholinesterase; Cr, creatinine; TCPy, trichloro-2-pyridinol.