TableĀ 5

Comparisons of diagnostic accuracy of mesothelin in pleural fluid for differentiation of MPM from different control subpopulations

MPM vs other cancersMPM vs benign diseases
Studies (reference numbers)23, 34, 36, 41, 42, 4836, 41, 42, 48
Sensitivity (95% CI)0.75 (0.69 to 0.80)0.75 (0.67 to 0.82)
Heterogeneity* (p value)1.36 (0.929)1.08 (0.783)
Specificity (95% CI)0.76 (0.71 to 0.82)0.87 (0.80 to 0.93)
Heterogeneity (p value)4.88 (0.430)6.74 (0.081)
PLR (95% CI)2.95 (2.32 to 3.75)4.74 (2.30 to 9.76)
Heterogeneity (p value)4.83 (0.437)7.01 (0.071)
NLR (95% CI)0.34 (0.27 to 0.43)0.30 (0.22 to 0.40)
Heterogeneity (p value)1.94 (0.857)1.83 (0.608)
DOR (95% CI)8.96 (5.78 to 13.89)16.87 (6.79 to 41.92)
Heterogeneity (p value)3.34 (0.648)5.26 (0.154)
AUC (SEM)0.809 (0.025)0.818 (0.050)
  • *Q value.

  • AUC, area under curve; DOR, diagnostic OR; MPM, malignant pleural mesothelioma; NLR, negative likelihood ratio; PLR, positive likelihood ratio.