Effect of prevalence of smoking habit, obesity, overweight and use of cardiovascular disease prevention drug therapy on annual incident ischaemic heart disease hospitalisation rates 1996–2006
| Lag0 | Lag1 | Lag2 | Lag3 | |||||
|---|---|---|---|---|---|---|---|---|
| IRR | 95% CI | IRR | 95% CI | IRR | 95% CI | IRR | 95% CI | |
| Adjustment for age, sex, year (random variable) and specified variables | ||||||||
| Smokers (%) | 1.02 | (1.01 to 1.02) | 1.02 | (1.02 to 1.02) | 1.02 | (1.02 to 1.02) | 1.02 | (1.02 to 1.02) |
| Obesity (%) | 1.05 | (1.04 to 1.05) | 1.05 | (1.05 to 1.05) | 1.05 | (1.05 to 1.05) | 1.06 | (1.05 to 1.06) |
| Overweight (%) | 1.04 | (1.04 to 1.04) | 1.04 | (1.04 to 1.04) | 1.03 | (1.03 to 1.04) | 1.03 | (1.03 to 1.03) |
| Drug use (×10 DHDs*)† | 0.97 | (0.97 to 0.98) | 0.97 | (0.97 to 0.97) | 0.97 | (0.97 to 0.97) | 0.97 | (0.96 to 0.97) |
| Statins† | 0.92 | (0.91 to 0.93) | 0.91 | (0.90 to 0.92) | 0.90 | (0.88 to 0.91) | 0.87 | (0.85 to 0.90) |
| Antihypertensive drugs† | 0.95 | (0.94 to 0.95) | 0.94 | (0.94 to 0.95) | 0.94 | (0.94 to 0.94) | 0.93 | (0.93 to 0.94) |
| Antidiabetic drugs† | 0.81 | (0.79 to 0.83) | 0.81 | (0.79 to 0.83) | 0.80 | (0.79 to 0.81) | 0.78 | (0.77 to 0.79) |
| Antiplatelet drugs† | 0.77 | (0.76 to 0.79) | 0.77 | (0.75 to 0.79) | 0.75 | (0.74 to 0.77) | 0.72 | (0.70 to 0.74) |
| Multivariate adjustment‡ | ||||||||
| Smokers (%) | 1.01 | (1.01 to 1.01) | 1.02 | (1.01 to 1.02) | 1.02 | (1.02 to 1.02) | 1.02 | (1.02 to 1.02) |
| Obesity (%) | 1.03 | (1.03 to 1.03) | 1.03 | (1.03 to 1.04) | 1.03 | (1.03 to 1.04) | 1.03 | (1.03 to 1.04) |
| Overweight (%) | 1.03 | (1.03 to 1.03) | 1.03 | (1.03 to 1.03) | 1.03 | (1.02 to 1.03) | 1.03 | (1.03 to 1.03) |
| Drug use (×10 DHDs*)† | 0.96 | (0.96 to 0.97) | 0.96 | (0.96 to 0.97) | 0.96 | (0.96 to 0.96) | 0.96 | (0.96 to 0.96) |
| Statins† | 0.90 | (0.89 to 0.91) | 0.89 | (0.88 to 0.90) | 0.87 | (0.86 to 0.89) | 0.85 | (0.83 to 0.87) |
| Antihypertensive drugs† | 0.92 | (0.91 to 0.93) | 0.92 | (0.91 to 0.93) | 0.92 | (0.92 to 0.93) | 0.92 | (0.92 to 0.93) |
| Antidiabetic drugs† | 0.73 | (0.68 to 0.77) | 0.74 | (0.71 to 0.77) | 0.75 | (0.73 to 0.77) | 0.75 | (0.74 to 0.75) |
| Antiplatelet drugs† | 0.70 | (0.66 to 0.73) | 0.70 | (0.67 to 0.73) | 0.70 | (0.68 to 0.71) | 0.68 | (0.67 to 0.70) |
Models for exposure–effect lags of 0, 1, 2 and 3 years.
*DHDs: Number of Defined Daily Doses per 1000 inhabitants per day.
†Not adjusted among themselves because collinearity.
‡Adjusted for variables specified in the table plus age, sex, year of discharge as a random-effect variable, prevalence (%) of arterial hypertension, prevalence (%) of hypercholesterolaemia, prevalence (%) of mellitus diabetes and the number of hospital beds in intensive care and coronary care units.