Table 5

Participant characteristics associated with rates of mortality after first sepsis events

CharacteristicsHR (95% CI)p Value
Demographics
Sex (male vs female)1.37 (1.002 to 1.88)0.048
Health status—physical composite score
 Quintile 1Referent
 Quintile 20.68 (0.46 to 1.01)0.06
 Quintile 30.55 (0.36 to 0.84)0.006
 Quintile 40.51 (0.33 to 0.79)0.002
 Quintile 50.59 (0.35 to 0.99)0.045
Chronic medical conditions
Cancer history1.68 (1.24 to 2.27)0.001
Chronic kidney disease1.43 (1.05 to 1.95)0.02
Deep vein thrombosis0.63 (0.38 to 1.04)0.07
Diabetes1.57 (1.17 to 2.11)0.003
Dyslipidaemia0.73 (0.55 to 0.98)0.04
Hypertension1.46 (1.07 to 2.00)0.02
Obesity (elevated waist circumference or body mass index ≥30 kg/m2)0.74 (0.56 to 0.99)0.04
Hospital course
Infection type
 LungReferent
 Kidney0.80 (0.55 to 1.17)0.24
 Abdominal0.48 (0.29 to 0.78)0.004
 Skin0.79 (0.43 to 1.43)0.43
 Sepsis0.98 (0.58 to 1.67)0.96
 Other1.33 (0.72 to 2.46)0.37
Admission to intensive care unit2.02 (1.40 to 2.91)<0.001
Sequential organ failure score
 0Referent
 11.10 (0.71 to 1.71)0.68
 21.25 (0.79 to 2.00)0.34
 3–41.66 (1.06 to 2.58)0.03
 5+3.62 (2.23 to 5.88)<0.001
  • Hospital course data based on first sepsis episode only. Only variables associated with early death are listed—full model listed in online supplementary appendix 3.

  • Includes individuals experiencing sepsis only.