Factors associated with HSV shedding rates*
| Variable | Univariable model | p Value | Multivariable model | p Value |
|---|---|---|---|---|
| HAART | ||||
| No | 1.00 | 1.00 | ||
| Yes | 1.55 (0.83 to 2.87) | 0.17 | 1.05 (0.43 to 2.58) | 0.78 |
| Age (per decade) | 1.18 (0.90 to 1.54) | 0.24 | ||
| Female n (%) | ||||
| Female | 1.00 | 1.00 | ||
| Male | 0.92 (0.43 to 1.95) | 0.83 | 0.79 (0.36 to 1.72) | 0.76 |
| HIV risk factor—n (%) | ||||
| Non-MSM | 1.00 | |||
| MSM | 1.00 (0.52 to 1.94) | 0.99 | ||
| Time since HIV diagnosis (per decade) | 1.48 (0.97 to 2.24) | 0.07 | 1.37 (0.74 to 2.54) | 0.72 |
| Immigrated to Canada within 10 years | ||||
| No | 1.00 | 1.00 | ||
| Yes | 0.67 (0.32 to 1.41) | 0.29 | 0.83 (0.32 to 2.17) | 0.67 |
| Baseline CD4 count | ||||
| Cells/mm3 (per 100) | 0.99 (0.88 to 1.13) | 0.96 | 0.99 (0.87 to 1.13) | 0.71 |
| Percentage | 0.97 (0.94 to 1.01) | 0.18 | ||
| Baseline HIV viral load (log copies/mL) | 0.93 (0.74 to 1.18) | 0.55 | ||
| History of oral herpes | ||||
| No | 1.00 | |||
| Yes | 1.00 (0.52 to 1.92) | 0.99 | ||
| History of anogenital herpes | ||||
| No | 1.00 | |||
| Yes | 2.41 (1.01 to 5.77) | 0.05 | ||
*Values shown are ORs (95% CIs) for shedding of HSV-1 and/or HSV-2.
HAART, highly active antiretroviral therapy; HSV, herpes simplex virus; MSM, men who have sex with men.