Risk for sick leave, permanent disability pension and mortality in CAB by aetiological agent compared with blood culture-negative controls
| Streptococcus pneumoniae (N=177) | Other Gram-positive (N=78) | Escherichia coli (N=103) | Other Gram-negative (N=78) | Polymicrobial (N=14) | |
|---|---|---|---|---|---|
| Sick leave, ≥4 weeks | |||||
| Risk, n (% of N) | 75 (42.4) | 44 (56.4) | 30 (29.1) | 30 (38.5) | 2 (14.3) |
| Adj. RD % (95% CI)* | 15.3 (8.0 to 22.6) | 30.1 (19.2 to 41.1) | 3.5 (−5.2 to 12.2) | 12.8 (2.1 to 23.5) | −6.4 (−24.3 to 11.5) |
| Adj. RR (95% CI)* | 1.57 (1.32 to 1.87) | 2.03 (1.66 to 2.49) | 1.14 (0.84 to 1.54) | 1.46 (1.10 to 1.93) | 0.55 (0.15 to 2.03) |
| Sick leave, ≥52 weeks | |||||
| Risk, n (% of N) | 9 (5.1) | 11 (14.1) | 2 (1.9) | 3 (3.8) | 1 (7.1) |
| Adj. RD % (95% CI)* | 1.9 (−1.3 to 5.0) | 11.5 (3.7 to 19.3) | −1.2 (−1.8 to −0.1) | 1.3 (−3.0 to 5.6) | 5.9 (−8.7 to 20.4) |
| Adj. RR (95% CI)* | 1.73 (0.90 to 3.33) | 4.65 (2.62 to 8.24) | 0.64 (0.16 to 2.56) | 1.33 (0.44 to 4.07) | 2.49 (0.36 to 17.29) |
| Disability pension, 1 year | |||||
| Risk, n (% of N) | 6 (3.4) | 2 (2.6) | 2 (1.9) | 2 (2.6) | 0 (0) |
| Adj. RD % (95% CI)* | 0.5 (−2.2 to 3.1) | −0.8 (−4.3 to 2.6) | −1.7 (4.5 to 1.0) | −0.5 (−3.9 to 2.9) | −3.1 (−4.7 to −1.5) |
| Adj. RR (95% CI)* | 1.63 (0.66 to 4.05) | 0.79 (0.18 to 3.54) | 0.35 (0.07 to 4.75) | 1.19 (0.30 to 4.75) | – |
| Mortality, 30 days | |||||
| Risk, n (% of N) | 3 (1.7) | 5 (6.4) | 5 (4.9) | 2 (2.6) | 3 (21.4) |
| Adj. RD % (95% CI)* | −0.1 (−2.1 to 1.8) | 4.6 (−0.8 to 10.0) | 3.0 (−1.2 to 7.2) | 0.8 (−2.6 to 4.3) | 20.0 (−1.5 to 41.5) |
| Adj. RR (95% CI)* | 1.05 (0.30 to 3.67) | 3.82 (1.49 to 9.81) | 1.90 (0.55 to 6.61) | 1.81 (0.45 to 7.34) | 13.97 (3.26 to 59.86) |
| Mortality, 1 year | |||||
| Risk, n (% of N) | 8 (4.5) | 12 (15.4) | 9 (8.7) | 3 (3.8) | 4 (28.6) |
| Adj. RD % (95% CI)* | −0.1 (−3.2 to 3.0) | 10.1 (2.4 to 17.8) | 3.6 (−1.6 to 8.7) | −0.8 (−5.0 to 3.5) | 23.8 (−0.4 to 48.0) |
| Adj. RR (95% CI)* | 0.81 (0.36 to 1.81) | 3.46 (2.22 to 5.38) | 1.97 (1.04 to 3.73) | 0.67 (0.19 to 2.35) | 3.55 (0.78 to 16.10) |
*Risk difference and relative risk pertaining to patients with CAB versus blood culture-negative controls (absolute risk estimates for controls can be found in table 2). Risk difference and relative risk computed by log-binomial regression (sick leave analyses) and regression analyses based on pseudo-observations (disability pension and mortality analyses). Estimates are Adj for age, gender, Charlson comorbidity score and alcoholism-related disease (due to few events, 30-day mortality estimates are Adj for age and gender only).
Adj, adjusted; CAB, community-acquired bacteraemia.