Table 2

List of evidence used to support medicinal product withdrawals in all EU member states between 2002 and 2011 derived from EMA reports, PubMed literature search and websites of competent authorities

Drug nameCase reportsAnimal studiesCase–controlCohortRCTsMeta-analysis*Others
RofecoxibXxxxX
ThioridazineXXxxX
ValdecoxibXxX
RosiglitazoneXxxxX
SibutramineXxx
OrciprenalineXx
BenfluorexXxxx
ClobutinolXXx
BuflomedilXX
VeraliprideX
RimonabantXxX
CarisoprodolXXxxx
Aceprometazine+Acepromazine+ClorazepateXx
DextropropoxypheneXx
NefazodoneXx
Ximelagatran/melagatranx
LumiracoxibXx
SitaxentanXX
BufexamacXXx
  • *Other studies include non-randomised and/or not controlled clinical trials and incidence studies.

  • EMA, European Medicines Agency; EU, European Union.