Table 1

Association of CYP2E1 polymorphisms to risk of GIC

Cases, NControls, NOR (95% CI)p Value
C-1019T SNP*
Allele
 c12728611.00 (Reference)
 c2781791.38 (1.02 to 1.86)0.038†
Genotype
 c1/c11063591.00 (Reference)
 c1/c2601431.42 (0.98 to 2.06)0.065
 c2/c29181.69 (0.74 to 3.88)0.241
 c1/c2+c2/c2691611.45 (1.02 to 2.07)0.042†
T7678A SNP*
Allele
 D2778061.00 (Reference)
 C732340.91 (0.68 to 1.22)0.552
Genotype
 D/D1113201.00 (Reference)
 D/C551660.96 (0.66 to 1.39)0.850
 C/C9340.76 (0.36 to 1.64)0.583
 D/C+C/C642000.92 (0.65 to 1.32)0.719
C-1019T+T7678A SNPs
Allele
 c1+D54916671.00 (Reference)
 c2+C1514131.11 (0.90 to 1.37)0.329
Genotype
 c1/c1+D/D2176791.00 (Reference)
 c1/c2+D/C1153091.17 (0.90 to 1.52)0.277
 c1/c2+C/C691771.22 (0.89 to 1.68)0.245
 c2/c2+D/C641841.09 (0.79 to 1.50)0.617
 c2/c2+C/C18521.08 (0.62 to 1.89)0.773
  • *In Hardy-Weinberg equilibrium (χ2<5.991, df=2).

  • †Statistically significant (p<0.05).

  • GIC, gastrointestinal cancer; SNP, single nucleotide polymorphism.