Baseline characteristics for all fibrate-exposed and matched fibrate and non-exposed controls
| Parameter | All fibrate patients | Fibrate matched | Non-exposed controls | ||||
|---|---|---|---|---|---|---|---|
| n | 5038 | 3176 | 3176 | ||||
| Follow-up (years) (mean, SD) | 5.2 | (3.2) | 5.1 | (3.2) | 5.0 | (3.2) | |
| Matched variables | |||||||
| Age on index date (years) (mean, SD) | 60.9 | (11.8) | 61.8 | (10.7) | 61.8 | (10.7) | |
| Age on diabetes presentation (years) (mean, SD) | 57.1 | (11.7) | 58.5 | (10.4) | 58.6 | (10.5) | |
| Females (n,%) | 2203 | (43.7%) | 1295 | (40.8%) | 1295 | (40.8%) | |
| Duration of diabetes (years) (mean, SD) | 3.9 | (3.8) | 3.2 | (3.0) | 3.3 | (3.0) | |
| Systolic BP (mm Hg) (mean, SD) | 137.8 | (16.5) | 136.5 | (13.4) | 136.5 | (13.4) | |
| HbA1c (%, SD) | 7.4 | (1.6) | 7.1 | (1.2) | 7.1 | (1.1) | |
| Prior statin use (n,%) | 3781 | (75.0%) | 2307 | (72.6%) | 2307 | (72.6%) | |
| Unmatched variables | p Value | ||||||
| BMI (kg/m2) (mean, SD) | 31.1 | (5.4) | 30.7 | (5.7) | 30.6 | (6.1) | 0.330 |
| Diastolic BP (mm Hg) (mean, SD) | 79.4 | (9.5) | 78.9 | (9.1) | 78.7 | (9.1) | 0.222 |
| Total cholesterol (mmol/L) (mean, SD) | 5.6 | (1.3) | 5.6 | (1.4) | 4.7 | (1.1) | <0.001 |
| HDL (mmol/L) (mean, SD) | 1.2 | (0.4) | 1.1 | (0.4) | 1.3 | (0.4) | <0.001 |
| LDL (mmol/L) (mean, SD) | 3.1 | (1.2) | 3.1 | (1.2) | 2.6 | (0.9) | <0.001 |
| Triglycerides (mmol/L) (mean, SD) | 3.7 | (2.4) | 3.2 | (1.6) | 1.9 | (1.0) | <0.001 |
| GP contacts in preceding year (mean, SD) | 13.9 | (10.2) | 13.4 | (9.9) | 12.6 | (10.3) | 0.001 |
| Charlson index (mean, SD) | 1.9 | (1.3) | 2.0 | (1.4) | 2.0 | (1.4) | 0.404 |
BMI, body mass index, BP, blood pressure; GP, general practitioner, HbA1c, glycated haemoglobin; HDL, high-density lipoprotein; LDL, low-density lipoprotein.