Five-year mortality following a brain tumour diagnosis among patients with and without multiple sclerosis (MS)
| Events/patients (%) | Unadjusted | Adjusted* | ||||
|---|---|---|---|---|---|---|
| MS | No MS | HR (95% CI) | p Value | HR (95% CI) | p Value | |
| N=110 (10.9%) | N=898 (89.1%) | |||||
| Unstratified | ||||||
| Cohort | ||||||
| No MS | – | 478/898 | Reference | |||
| MS | 45/110 | – | 0.75 (0.56 to 1.02) | 0.070 | 0.91 (0.67 to 1.24) | 0.554 |
| Age (years) | 49.6† | 52.3† | 1.04 (1.04 to 1.05) | <0.001 | 1.05 (1.04 to 1.05) | <0.001 |
| Sex | ||||||
| Male | 25/44 (40.0) | 177/283 (31.5) | Reference | Reference | ||
| Female | 20/66 (60.0) | 301/615 (68.5) | 0.65 (0.55 to 0.78) | <0.001 | 0.89 (0.74 to 1.07) | 0.201 |
| Brain tumour histological classification | ||||||
| Low grade | 17/58 (52.7) | 131/460 (51.2) | Reference | Reference | ||
| High grade | 22/32 (29.1) | 284/333 (37.1) | 4.76 (3.89 to 5.82) | <0.001 | 5.11 (4.14 to 6.31) | <0.001 |
| Uncertain grade | 6/20 (18.2) | 63/105 (11.7) | 2.44 (1.83 to 3.25) | <0.001 | 2.47 (1.85 to 3.30) | <0.001 |
| Stratified by brain tumour histology | ||||||
| Low grade | ||||||
| No MS | – | 131/460 | Reference | Reference | ||
| MS | 17/58 | – | 1.10 (0.66 to 1.82) | 0.722 | 1.14 (0.68 to 1.89) | 0.618 |
| High grade | ||||||
| No MS | – | 284/333 | Reference | Reference | ||
| MS | 22/32 | – | 0.75 (0.49 to 1.16) | 0.200 | 0.91 (0.58 to 1.42) | 0.665 |
| Uncertain grade | ||||||
| No MS | – | 63/105 | Reference | Reference | ||
| MS | 6/20 | – | 0.39 (0.17 to 0.89) | 0.026 | 0.67 (0.27 to 1.68) | 0.394 |
*HRs adjusted for age at brain tumour diagnosis, level of malignancy, sex, region of residence and socioeconomic index.
†Mean age in years (HRs are for each 1-year increase in age).