Table 1

Antinuclear antibody immunofluorescence microscopy staining patterns in relation to clinical and laboratory features among 219 patients with systemic lupus erythematosus

H-ANA (%)S-ANA (%)HS-ANA (%)N-ANA* (%)C-ANA (%)oANA (%)
(n=119)(n=49)(n=24)(n=19)p ValueCramer's V(n=3)(n=5)Total (%)
Clinical feature (ACR–82)
 Malar rash42.053.141.731.60.38 08043.8
 Discoid lupus12.618.420.810.50.57† 332015.1
 Photosensitivity47.965.358.336.80.09 338052.5
 Oral ulcers10.116.312.510.50.68† 0011.4
 Arthritis76.563.3–91.789.50.020.2310010077.2
 Serositis42.938.825.047.40.38 1002040.6
 Pleuritis38.734.725.036.80.64 1002036.5
 Pericarditis16.014.30.015.80.15† 33013.7
 Renal disorder24.416.329.215.80.49 33021.9
 Neurological disorder1.7–8.28.310.50.04†0.173305.0
 Seizures0.8–6.18.310.50.02†0.193304.1
 Psychosis0.82.00.05.30.22† 001.4
 Haematological disorder48.759.258.342.10.45 33050.2
 Immunological disorder64.7+24.5–33.331.6<0.0010.3733047.5
 Antinuclear antibody100100100100 100100100
 ≥6 fulfilled ACR criteria26.924.520.815.80.73 33024.2
 SDI score ≥159.730.6–54.257.90.0070.24676052.5
Laboratory feature
 Haemolytic anemia2.58.24.25.30.30† 004.1
 Leukocytopenia29.430.633.321.10.84 33028.8
 Lymphocytopenia27.732.733.331.60.90 0028.8
 Thrombocytopenia10.116.312.55.30.59† 0011.0
 Lupus anticoagulant‡34.624.333.338.50.68 335032.5
 Anti-dsDNA63.9+12.2–33.326.3<0.0010.4533043.8
 Anti-Sm3.416.7+4.210.50.022†0.21007.0
 Anti-Ro/SSA32.843.862.5+36.80.0470.2033038.5
 Anti-La/SSB7.012.833.3+0.00.002†0.290011.8
 Anti-snRNP6.9–47.8+13.622.2<0.001†0.430020.2
  • *Staining pattern±combination with other pattern(s).

  • †Fisher's exact test.

  • ‡Not analysed in all patients; H-ANA: n=81, S-ANA: n=37, HS-ANA: n=18, N-ANA: n=13, C-ANA: n=3, oANA: n=2.

  • + = positive association, − = negative association.

  • ACR-82, the 1982 American College of Rheumatology criteria; C-ANA, centromeric; H-ANA, homogenous; HS-ANA, homogenous/peckled; N-ANA, nucleolar; oANA, other pattern; S-ANA, speckled.