H-ANA (%) | S-ANA (%) | HS-ANA (%) | N-ANA* (%) | C-ANA (%) | oANA (%) | ||||
---|---|---|---|---|---|---|---|---|---|
(n=119) | (n=49) | (n=24) | (n=19) | p Value | Cramer's V | (n=3) | (n=5) | Total (%) | |
Clinical feature (ACR–82) | |||||||||
Malar rash | 42.0 | 53.1 | 41.7 | 31.6 | 0.38 | 0 | 80 | 43.8 | |
Discoid lupus | 12.6 | 18.4 | 20.8 | 10.5 | 0.57† | 33 | 20 | 15.1 | |
Photosensitivity | 47.9 | 65.3 | 58.3 | 36.8 | 0.09 | 33 | 80 | 52.5 | |
Oral ulcers | 10.1 | 16.3 | 12.5 | 10.5 | 0.68† | 0 | 0 | 11.4 | |
Arthritis | 76.5 | 63.3– | 91.7 | 89.5 | 0.02 | 0.23 | 100 | 100 | 77.2 |
Serositis | 42.9 | 38.8 | 25.0 | 47.4 | 0.38 | 100 | 20 | 40.6 | |
Pleuritis | 38.7 | 34.7 | 25.0 | 36.8 | 0.64 | 100 | 20 | 36.5 | |
Pericarditis | 16.0 | 14.3 | 0.0 | 15.8 | 0.15† | 33 | 0 | 13.7 | |
Renal disorder | 24.4 | 16.3 | 29.2 | 15.8 | 0.49 | 33 | 0 | 21.9 | |
Neurological disorder | 1.7– | 8.2 | 8.3 | 10.5 | 0.04† | 0.17 | 33 | 0 | 5.0 |
Seizures | 0.8– | 6.1 | 8.3 | 10.5 | 0.02† | 0.19 | 33 | 0 | 4.1 |
Psychosis | 0.8 | 2.0 | 0.0 | 5.3 | 0.22† | 0 | 0 | 1.4 | |
Haematological disorder | 48.7 | 59.2 | 58.3 | 42.1 | 0.45 | 33 | 0 | 50.2 | |
Immunological disorder | 64.7+ | 24.5– | 33.3 | 31.6 | <0.001 | 0.37 | 33 | 0 | 47.5 |
Antinuclear antibody | 100 | 100 | 100 | 100 | 100 | 100 | 100 | ||
≥6 fulfilled ACR criteria | 26.9 | 24.5 | 20.8 | 15.8 | 0.73 | 33 | 0 | 24.2 | |
SDI score ≥1 | 59.7 | 30.6– | 54.2 | 57.9 | 0.007 | 0.24 | 67 | 60 | 52.5 |
Laboratory feature | |||||||||
Haemolytic anemia | 2.5 | 8.2 | 4.2 | 5.3 | 0.30† | 0 | 0 | 4.1 | |
Leukocytopenia | 29.4 | 30.6 | 33.3 | 21.1 | 0.84 | 33 | 0 | 28.8 | |
Lymphocytopenia | 27.7 | 32.7 | 33.3 | 31.6 | 0.90 | 0 | 0 | 28.8 | |
Thrombocytopenia | 10.1 | 16.3 | 12.5 | 5.3 | 0.59† | 0 | 0 | 11.0 | |
Lupus anticoagulant‡ | 34.6 | 24.3 | 33.3 | 38.5 | 0.68 | 33 | 50 | 32.5 | |
Anti-dsDNA | 63.9+ | 12.2– | 33.3 | 26.3 | <0.001 | 0.45 | 33 | 0 | 43.8 |
Anti-Sm | 3.4 | 16.7+ | 4.2 | 10.5 | 0.022† | 0.21 | 0 | 0 | 7.0 |
Anti-Ro/SSA | 32.8 | 43.8 | 62.5+ | 36.8 | 0.047 | 0.20 | 33 | 0 | 38.5 |
Anti-La/SSB | 7.0 | 12.8 | 33.3+ | 0.0 | 0.002† | 0.29 | 0 | 0 | 11.8 |
Anti-snRNP | 6.9– | 47.8+ | 13.6 | 22.2 | <0.001† | 0.43 | 0 | 0 | 20.2 |
*Staining pattern±combination with other pattern(s).
†Fisher's exact test.
‡Not analysed in all patients; H-ANA: n=81, S-ANA: n=37, HS-ANA: n=18, N-ANA: n=13, C-ANA: n=3, oANA: n=2.
+ = positive association, − = negative association.
ACR-82, the 1982 American College of Rheumatology criteria; C-ANA, centromeric; H-ANA, homogenous; HS-ANA, homogenous/peckled; N-ANA, nucleolar; oANA, other pattern; S-ANA, speckled.