LTFU risk factors in patients on antiretroviral treatment (stage 4)
| Cox regression, LTFU hazard rates (HR) | ||||
|---|---|---|---|---|
| Stage 4 | Univariate analysis | Multivariate analysis | ||
| LTFU risk factors | HR (95% CI) | p Value | HR (95% CI) | p Value |
| Sex | ||||
| Male | 1.21 (1.06 to 1.38) | <0.01 | 1.41 (1.15 to 1.74) | <0.01 |
| Female | 1.00 | – | 1.00 | – |
| Age stratification (years) | ||||
| ≤30 | 1.00 | – | 1.00 | – |
| 30–39 | 0.83 (0.71 to 0.97) | 0.02 | 0.68 (0.54 to 0.86) | <0.01 |
| ≥ 40 | 0.83 (0.71 to 0.97) | 0.02 | 0.62 (0.48 to 0.79) | <0.01 |
| HIVtype | ||||
| HIV-1 | 1.00 | – | 1.00 | – |
| HIV-2 | 1.12 (0.95 to 1.33) | 0.17 | 1.39 (1.08 to 1.80) | 0.01 |
| HIV-1/2 | 1.22 (1.02 to 1.46) | 0.03 | 1.65 (1.24 to 2.18) | <0.01 |
| CD4 cell count (cells/μL) | ||||
| ≤200 | 2.05 (1.63 to 2.56) | <0.01 | 2.71 (2.04 to 3.61) | <0.01 |
| 201–350 | 1.83 (1.44 to 2.31) | <0.01 | 2.31 (1.71 to 3.13) | <0.01 |
| >350 | 1.00 | – | 1.00 | – |
| Anaemia* | ||||
| Yes | 1.19 (0.95 to 1.48) | 0.13 | – | – |
| No | 1.00 | – | – | – |
| Nutritional status (kg/m2) | ||||
| BMI≤18.5 | 1.58 (1.38 to 1.81) | <0.01 | 1.51 (1.23 to 1.87) | <0.01 |
| BMI>18.5 | 1.00 | – | 1.00 | – |
| Marital status | ||||
| Single | 0.96 (0.82 to 1.11) | 0.57 | – | – |
| Married | 1.00 | – | – | – |
| Divorced | 0.80 (0.60 to 1.08) | 0.15 | – | – |
| Widowed | 0.91 (0.76 to 1.09) | 0.31 | – | – |
| Religion | ||||
| Muslim | 1.00 | – | 1.00 | – |
| Catholic | 0.74 (0.63 to 0.87) | <0.01 | 0.75 (0.59 to 0.96) | 0.02 |
| Protestant | 0.79 (0.61 to 1.03) | 0.08 | 0.79 (0.54 to 1.15) | 0.21 |
| Animist | 0.98 (0.84 to 1.15) | 0.83 | 1.09 (0.86 to 1.39) | 0.47 |
| Schooling | ||||
| Yes | 1.00 | – | 1.00 | – |
| No | 1.21 (1.06 to 1.38) | <0.01 | 1.22 (0.98 to 1.52) | 0.08 |
| Geographic site of residence | ||||
| Bissau | 1.00 | – | – | – |
| Outside Bissau | 1.06 (0.85 to 1.31) | 0.61 | – | – |
*Haemoglobin below normal range: men >13 and women >12 mg/dL.
BMI, body mass index; LTFU, loss to follow-up.